1-Benzyl-4-chloroindole

Base Information

• Chemical Name: 1-Benzyl-4-chloroindole
• CAS No.: 77801-60-6
• Molecular Formula: C15H12ClN
• Molecular Weight: 241.72
• Hs Code.: 2933990090
• Mol file: 77801-60-6.mol

Synonyms:4-chloro-1-benzyl-1H-indole;N-benzyl-4-chloro-indole;1-Benzyl-4-chloro-1H-indole;

Chemical Property of 1-Benzyl-4-chloroindole

Chemical Property:

• Boiling Point: 407.1 °C at 760 mmHg
• Flash Point: 200 °C
• PSA: 4.93000
• Density: 1.15 g/cm³
• LogP: 4.34300
• Storage Temp.: 2-8°C

Purity/Quality:

95+% ^*data from raw suppliers

1-Benzyl-4-chloro-1H-indole 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-Benzyl-4-chloroindole

There total 5 articles about 1-Benzyl-4-chloroindole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

4-chloro-1H-indole (25235-85-2) + benzyl bromide (100-39-0) → 4-chloro-1-benzyl-1H-indole (77801-60-6)

Guidance literature:

4-chloro-1H-indole; With sodium hydride; In N,N-dimethyl-formamide; at 20 ℃; for 1h;

benzyl bromide; In N,N-dimethyl-formamide; at 20 ℃; for 20h;

DOI:10.1021/ja036985c

Reference yield: 91.0%

4-chloro-1H-indole (25235-85-2) + benzyl chloride (100-44-7) → 4-chloro-1-benzyl-1H-indole (77801-60-6)

Guidance literature:

4-chloro-1H-indole; With sodium hydride; In N,N-dimethyl-formamide; mineral oil; at 0 ℃; for 0.5h; Cooling with ice; Inert atmosphere;

benzyl chloride; In N,N-dimethyl-formamide; mineral oil; at 0 - 20 ℃; for 15h; Inert atmosphere;

DOI:10.1002/anie.201502626

Reference yield:

4-chloro-1H-indole (25235-85-2) + n-tetrabutylammonium acid sulfate + benzyl chloride (100-44-7) → 4-chloro-1-benzyl-1H-indole (77801-60-6)

Guidance literature:

With sodium hydroxide; In benzene;

upstream raw materials:

4-chloro-1H-indole

benzyl bromide

tetra(n-butyl)ammonium hydrogensulfate

benzyl chloride

Downstream raw materials:

1-benzyl-4-chloro-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-indole

1-benzyl-4-chloro-3-iodoindole

1-benzyl-3-bromo-4-chloroindole

2-benzyl-6-pyridin-3-yl-2,6-dihydro-2-aza-dibenzo[cd,h]azulen-7-one

Refernces

• 1、 Sun, Nan,Hong, Lingfen,Huang, Fang,Ren, Hong,Mo, Weimin,Hu, Baoxiang,Shen, Zhenlu,Hu, Xinquan. "General and efficient synthesis of 2,3-unsubstituted indoles catalyzed by acidic mesoporous molecular sieves". . p. 3927 - 3933. Retrieved 2013/06/27.
• 2、 Liu, Qiang,Li, Gang,Yi, Hong,Wu, Pan,Liu, Jie,Lei, Aiwen. "Pd-catalyzed direct and selective C-H functionalization: C3-acetoxylation of indoles". supporting information; experimental part. p. 2353 - 2357. Retrieved 2011/04/24.