5-CHLORO-3-METHYL-PYRIDINE-2-CARBOXYLIC ACID

Base Information

• Chemical Name: 5-CHLORO-3-METHYL-PYRIDINE-2-CARBOXYLIC ACID
• CAS No.: 886365-46-4
• Molecular Formula: C7H6ClNO2
• Molecular Weight: 171.583
• Hs Code.: 2933399090
• Mol file: 886365-46-4.mol

Synonyms:5-chloro-3-methylpyridine-2-carboxylic acid

Chemical Property of 5-CHLORO-3-METHYL-PYRIDINE-2-CARBOXYLIC ACID

Chemical Property:

• Vapor Pressure: 0mmHg at 25°C
• Boiling Point: 323.878oC at 760 mmHg
• PKA: 3.04±0.37(Predicted)
• Flash Point: 149.676oC
• PSA: 50.19000
• Density: 1.39g/cm3
• LogP: 1.74160
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C

Purity/Quality:

98%, ^*data from raw suppliers

5-Chloro-3-methylpyridine-2-carboxylicacid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 5-Chloro-3-methylpyridine-2-carboxylic acid

Technology Process of 5-CHLORO-3-METHYL-PYRIDINE-2-CARBOXYLIC ACID

There total 3 articles about 5-CHLORO-3-METHYL-PYRIDINE-2-CARBOXYLIC ACID which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

2,5 dichloropyridine (16110-09-1) + methanol (67-56-1) + carbon monoxide (201230-82-2) → 5-chloro-3-methylpyridine-2-carboxylic acid (886365-46-4)

Guidance literature:

With 1,1'-bis-(diphenylphosphino)ferrocene; triethylamine; palladium diacetate; In methanol; at 100 ℃; for 11h; under 2585.81 Torr;

Reference yield: 89.0%

5-chloro-3-methylpyridine-2-carbonitrile (156072-84-3) → 5-chloro-3-methylpyridine-2-carboxylic acid (886365-46-4)

Guidance literature:

In ethanol;

Reference yield:

2-bromine-3-methyl-5-chloropyridine (65550-77-8) → 5-chloro-3-methylpyridine-2-carboxylic acid (886365-46-4)

Guidance literature:

Multi-step reaction with 2 steps

2: ethanol

In ethanol;

upstream raw materials:

2,5 dichloropyridine

methanol

carbon monoxide

2-bromine-3-methyl-5-chloropyridine

Downstream raw materials:

N-(3-((4S,6S)-2-amino-4-(fluoromethyl)-6-(trifluoromethyl)-5,6-dihydro-4H-1,3-oxazin-4-yl)-4-fluorophenyl)-5-chloro-3-methylpyridine-2-carbothioamide

N-(3-((4S,6S)-2-amino-4-(fluoromethyl)-6-(trifluoromethyl)-5,6-dihydro-4H-1,3-oxazin-4-yl)-4-fluorophenyl)-5-chloro-3-methyl-2-pyridinecarboxamide

N-(3-((4S,6S)-2-amino-4-methyl-6-(trifluoromethyl)-5,6-dihydro-4H-1,3-oxazin-4-yl)-4,5-difluorophenyl)-5-chloro-3-methylpicolinamide

Refernces

• 1、 -. "BRIDGED BICYCLIC AMINO THIAZINE DIOXIDE COMPOUNDS AS INHIBITORS OF BETA-SECRETASE AND METHODS OF USE THEREOF". . . Retrieved 2015/02/19.
• 2、 -. "PERFLUORINATED CYCLOPROPYL FUSED 1,3-OXAZIN-2-AMINE COMPOUNDS AS BETA-SECRETASE INHIBITORS AND METHODS OF USE". . . Retrieved 2014/09/29.