Technology Process of Diethyl 2-(4-octanoylphenethyl)-2-acetamidomalonate
There total 6 articles about Diethyl 2-(4-octanoylphenethyl)-2-acetamidomalonate which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
aluminum (III) chloride; 1,2-dichloro-ethane;
at 0 - 20 ℃;
for 18.5h;
DOI:10.1039/c3ra40894a
- Guidance literature:
-
Multi-step reaction with 3 steps
1: LiAlH4 / tetrahydrofuran / 2 h / 20 °C
2: pyridine / 16 h / 20 °C
3: 64 percent / AlCl3 / 1,2-dichloro-ethane / 12 h / 20 °C
With
pyridine; lithium aluminium tetrahydride; aluminium trichloride;
In
tetrahydrofuran; 1,2-dichloro-ethane;
1: Reduction / 2: Acetylation / 3: Friedel-Crafts acylation;
DOI:10.1021/jm000173z
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: sodium ethoxide / ethanol / 0.5 h / 20 °C
1.2: ethanol / 3 h / 65 °C
2.1: LiAlH4 / tetrahydrofuran / 2 h / 20 °C
3.1: pyridine / 16 h / 20 °C
4.1: 64 percent / AlCl3 / 1,2-dichloro-ethane / 12 h / 20 °C
With
pyridine; lithium aluminium tetrahydride; aluminium trichloride; sodium ethanolate;
In
tetrahydrofuran; ethanol; 1,2-dichloro-ethane;
1.1: Metallation / 1.2: Alkylation / 2.1: Reduction / 3.1: Acetylation / 4.1: Friedel-Crafts acylation;
DOI:10.1021/jm000173z
