N-Hydroxyglycine

Base Information

• Chemical Name: N-Hydroxyglycine
• CAS No.: 3545-78-6
• Molecular Formula: C2H5NO3
• Molecular Weight: 91.0666
• Hs Code.: 2922509090
• NSC Number: 76386
• UNII: FVT2AQ968S
• DSSTox Substance ID: DTXSID60188959
• Nikkaji Number: J75.728D
• Wikidata: Q27117361
• Metabolomics Workbench ID: 55762
• ChEMBL ID: CHEMBL1645222
• Mol file: 3545-78-6.mol

Synonyms:N-Hydroxyglycine;2-(hydroxyamino)acetic acid;3545-78-6;(Hydroxyamino)acetic acid;GLYCINE, N-HYDROXY-;Hydroxyaminoacetic acid;Hydroxylamino acetic acid;Acetic acid, (hydroxyamino)-;NSC 76386;BRN 1743147;FVT2AQ968S;CHEBI:38049;NSC-76386;0-04-00-00542 (Beilstein Handbook Reference);hydroxyglycine;N-Hydroxy Glycine;N-HYDROXY-GLYCINE;2-(hydroxyamino)aceticacid;UNII-FVT2AQ968S;2-(hydroxyamino)-acetic acid;CHEMBL1645222;DTXSID60188959;NSC76386;AKOS006376625;LS-72683;EN300-103847;Q27117361;Z1205493750

Chemical Property of N-Hydroxyglycine

Chemical Property:

• Vapor Pressure: 1.07E-06mmHg at 25°C
• Melting Point: >126°C (dec.)
• Boiling Point: 361.9°Cat760mmHg
• Flash Point: 172.6°C
• PSA: 69.56000
• Density: 1.457g/cm³
• LogP: -0.55930
• Storage Temp.: Refrigerator, under inert atmosphere
• Solubility.: Water (Slightly)
• XLogP3: -3.3
• Hydrogen Bond Donor Count: 3
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 2
• Exact Mass: 91.026943022
• Heavy Atom Count: 6
• Complexity: 52.8

Purity/Quality:

99%, ^*data from raw suppliers

2-(Hydroxyamino)aceticAcid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C(C(=O)O)NO
• Uses: 2-(Hydroxyamino)acetic Acid is a novel lactase inhibitor.

Technology Process of N-Hydroxyglycine

There total 11 articles about N-Hydroxyglycine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

glyoxylic acid aldoxime (168208-95-5) → N-hydroxyglycine (3545-78-6)

Guidance literature:

With pH<3; sodium cyanoborohydride; In methanol; for 3h; Ambient temperature;

Reference yield: 76.0%

ethyl bromoacetate (105-36-2) + Benzaldoxime (932-90-1) → N-hydroxyglycine (3545-78-6)

Guidance literature:

ethyl bromoacetate; Benzaldoxime; With sodium; In ethanol; for 3h; pH=7;

With hydrogenchloride; for 0.5h; Reflux;

Reference yield: 72.0%

C7H7NO4 (110187-72-9) → N-hydroxyglycine (3545-78-6)

Guidance literature:

With hydrogenchloride; at 80 ℃; for 0.0833333h;

DOI:10.1248/cpb.34.3202

upstream raw materials:

N-hydroxy-N-nitroso-glycine

N-benzyliden-N-oxy-glycine

2-(benzyloxyamino)acetic acid

glyoxylic acid aldoxime

Downstream raw materials:

5-Chlor-2-<2-(N-acetoxy-acetamino)-acetamino>-benzophenon

L-Phenylalanin-N-hydroxy-glycin

L-γ-Benzyl-glutamyl-N-hydroxy-glycin

Carboxy-N-(3-hydroxy-4-methoxyphenylmethylen)methylamin-N-oxid

Refernces

• 1、 -. "DERMAL COMPOSITIONS CONTAINING UNNATURAL HYGROSCOPIC AMINO ACIDS". Page/Page column 26; 27. . Retrieved 2014/05/24.
• 2、 Jahngen, Edwin G.E.,Rossomando, Edward F.. "THE SYNTHESIS OF HADACIDIN: SODIUM CYANOBOROHYDRIDE REDUCTION OF α-OXIMINOIC ACIDS". . p. 601 - 606. Retrieved 2007/10/02.