4-Acetyl-4-phenylpiperidine hydrochloride

Base Information

• Chemical Name: 4-Acetyl-4-phenylpiperidine hydrochloride
• CAS No.: 10315-03-4
• Molecular Formula: C13H18ClNO
• Molecular Weight: 239.745
• Hs Code.: 29333999
• European Community (EC) Number: 233-694-0
• NSC Number: 57803
• UNII: XW2M3XY4FY
• DSSTox Substance ID: DTXSID50145672
• Mol file: 10315-03-4.mol

Synonyms:10315-03-4;4-Acetyl-4-phenylpiperidine hydrochloride;1-(4-phenylpiperidin-4-yl)ethanone hydrochloride;1-(4-Phenylpiperidin-4-yl)ethan-1-one hydrochloride;4-ACETYL-4-PHENYLPIPERIDINE HCl;1-(4-Phenylpiperidin-4-yl)ethan-1-one HCl;1-(4-phenylpiperidin-4-yl)ethanone;hydrochloride;EINECS 233-694-0;NSC-57803;MFCD00039037;ETHYLPHENOXYACETATE;XW2M3XY4FY;SCHEMBL917775;DTXSID50145672;JYDHZOIDIWUHDB-UHFFFAOYSA-N;NSC57803;NSC 57803;AKOS015888192;SB44046;TS-03348;4-acetyl 4-phenyl piperidine hydrochloride;4-acetyl-4-phenyl-piperidine hydrochloride;CS-0314359;FT-0617402;D88452;1-(4-phenylpiperidin-4-yl)ethanonehydrochloride;4-Acetyl-4-phenylpiperidine hydrochloride, 98%;J-000885;Ethanone,1-(4-phenyl-4-piperidinyl)-,hydrochloride(1:1);Ethanone, 1-(4-phenyl-4-piperidinyl)-, hydrochloride (1:1);Ethanone,1-(4-phenyl-4-piperidinyl)-, hydrochloride (1:1)

Chemical Property of 4-Acetyl-4-phenylpiperidine hydrochloride

Chemical Property:

• Appearance/Colour: slightly yellow to beige powder
• Vapor Pressure: 0.000234mmHg at 25°C
• Melting Point: 232-234 °C(lit.)
• Boiling Point: 325.2 °C at 760 mmHg
• Flash Point: 125.7 °C
• PSA: 29.10000
• LogP: 3.02760
• Solubility.: water: soluble(lit.)
• Water Solubility.: almost transparency
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 2
• Exact Mass: 239.1076919
• Heavy Atom Count: 16
• Complexity: 225

Purity/Quality:

98%,99%, ^*data from raw suppliers

4-Acetyl-4-phenylpiperidine Hydrochloride ^*data from reagent suppliers

Safty Information:

• Safety Statements: 24/25

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Canonical SMILES: CC(=O)C1(CCNCC1)C2=CC=CC=C2.Cl
• Uses: Reactant for synthesis of neurotransmitter transport inhibitors with activity at dopamine receptor sites

Technology Process of 4-Acetyl-4-phenylpiperidine hydrochloride

There total 4 articles about 4-Acetyl-4-phenylpiperidine hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1,4-diacetyl 4-phenyl piperidine → 4-Acetyl-4-phenylpiperidine hydrochloride (10315-03-4)

Guidance literature:

1,4-diacetyl 4-phenyl piperidine; With water; sodium hydroxide; In methanol; at 20 ℃; for 10h;

With hydrogenchloride; In methanol; water; pH=2;

Reference yield:

p-phenylpyridine (939-23-1) → 4-Acetyl-4-phenylpiperidine hydrochloride (10315-03-4)

Guidance literature:

Multi-step reaction with 3 steps

1.1: indium / 7 h / 95 - 100 °C

2.1: palladium 10% on activated carbon; hydrogen / methanol / 10 h / 60 °C / Autoclave

3.1: sodium hydroxide; water / methanol / 10 h / 20 °C

3.2: pH 2

With indium; palladium 10% on activated carbon; water; hydrogen; sodium hydroxide; In methanol;

Reference yield:

1,4-diacetyl-1,4-dihydro-4-phenylpyridine (41225-59-6) → 4-Acetyl-4-phenylpiperidine hydrochloride (10315-03-4)

Guidance literature:

Multi-step reaction with 2 steps

1.1: palladium 10% on activated carbon; hydrogen / methanol / 10 h / 60 °C / Autoclave

2.1: sodium hydroxide; water / methanol / 10 h / 20 °C

2.2: pH 2

With palladium 10% on activated carbon; water; hydrogen; sodium hydroxide; In methanol;

upstream raw materials:

1-(1-benzyl-4-phenyl-[4]piperidyl)-ethanone; hydrochloride

p-phenylpyridine

1,4-diacetyl-1,4-dihydro-4-phenylpyridine

Downstream raw materials:

{(1S)-1-[4-phenyl-1-(propylsulfonyl)piperidin-4-yl]ethyl}amine

{(1R)-1-[4-phenyl-1-(propylsulfonyl)piperidin-4-yl]ethyl}amine

1-(4-phenyl-1-tosylpiperidin-4-yl)ethan-1-one

4-Acetyl-1-(2-(4-hydroxyphenoxy)ethyl)-4-phenylpiperidine hydrochloride

Refernces