1-Ethoxy-2-methylbenzene

Base Information

• Chemical Name: 1-Ethoxy-2-methylbenzene
• CAS No.: 614-71-1
• Molecular Formula: C9H12O
• Molecular Weight: 136.194
• DSSTox Substance ID: DTXSID80210327
• Nikkaji Number: J46.550J
• Wikidata: Q63409201
• ChEMBL ID: CHEMBL145657
• Mol file: 614-71-1.mol

Synonyms:1-Ethoxy-2-methylbenzene;o-Ethoxytoluene;614-71-1;Phenetole, o-methyl-;Benzene, 1-ethoxy-2-methyl-;1-Ethoxy-2-methyl-benzene;CHEMBL145657;2-Methylphenetole;ethoxytoluene;2-Ethoxytoluene;o-Methylphenetole;Ethyl o-tolyl ether;ORTHO-METHYLPHENETOLE;SCHEMBL254578;DTXSID80210327;BDBM50409747;AKOS005142974;A833243;Q63409201;F8883-7586

Chemical Property of 1-Ethoxy-2-methylbenzene

Chemical Property:

• Vapor Pressure: 1.02mmHg at 25°C
• Melting Point: 184-184.5 °C
• Refractive Index: 1.5080
• Boiling Point: 184°Cat760mmHg
• Flash Point: 64.2°C
• PSA: 9.23000
• Density: 0.931g/cm³
• LogP: 2.39370
• XLogP3: 3.1
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 2
• Exact Mass: 136.088815002
• Heavy Atom Count: 10
• Complexity: 90.7

Purity/Quality:

98%min ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CCOC1=CC=CC=C1C

Technology Process of 1-Ethoxy-2-methylbenzene

There total 15 articles about 1-Ethoxy-2-methylbenzene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

ethyl iodide (75-03-6) + ortho-cresol (95-48-7,77504-84-8) → 2-ethoxytoluene (614-71-1)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; at 20 ℃; for 15h;

Reference yield: 53.0%

boron trifluoride diethyl etherate (109-63-7) + ortho-cresol (95-48-7,77504-84-8) → 2-ethoxytoluene (614-71-1)

Guidance literature:

at 120 ℃; for 4h; Reflux;

DOI:10.3390/molecules24203720

Reference yield: 4.0%

1-(2-Vinyloxy-benzyl)-cyclohexa-2,5-dienecarboxylic acid → 2-ethoxytoluene (614-71-1) + 1-vinyloxy-2-methylbenzene (934-21-4) + 1-(Ethenyloxy)-2-benzylbenzene + 1-Ethoxy-2-benzylbenzene

Guidance literature:

With dibenzoyl peroxide; In benzene; for 48h; Title compound not separated from byproducts;

DOI:10.1039/a802024h

upstream raw materials:

ethyl bromide

potassium o-cresolate

diethyl sulfate

sodium o-cresolate

Downstream raw materials:

4-(4-ethoxy-3-methyl-phenyl)-4-oxo-butyric acid

2-methyl-4,6-dinitroaniline

3-methyl-5-nitro-aniline

4-ethoxy-3-methyl-aniline

Refernces

• 1、 -. "INHIBITORS OF ACETYL-COA CARBOXYLASE". Page/Page column 53. . Retrieved 2010/11/17.
• 2、 Pazo-Llorente, Roman,Bravo-Diaz, Carlos,Gonzalez-Romero, Elisa. "Solvolysis of some arenediazonium salts in binary EtOH/H2O mixtures under acidic conditions". . p. 3421 - 3428. Retrieved 2007/10/03.