6-CHLOROPIPERONAL

Base Information

• Chemical Name: 6-CHLOROPIPERONAL
• CAS No.: 15952-61-1
• Molecular Formula: C8H5ClO3
• Molecular Weight: 184.579
• Hs Code.: 2932999099
• Mol file: 15952-61-1.mol

Synonyms:6-Chloropiperonal;NSC 166400;6-Chlorobenzodioxole-5-carboxaldehyde;2-Chloro-4,5-methylenedioxybenzaldehyde;Piperonal,6-chloro- (6CI,8CI);

Chemical Property of 6-CHLOROPIPERONAL

Chemical Property:

• Vapor Pressure: 0.00152mmHg at 25°C
• Melting Point: 114-115 °C
• Refractive Index: 1.627
• Boiling Point: 295.5 °C at 760 mmHg
• Flash Point: 138.1 °C
• PSA: 35.53000
• Density: 1.485 g/cm³
• LogP: 1.88120
• Sensitive.: Air Sensitive
• Water Solubility.: Insoluble in water.

Purity/Quality:

99% ^*data from raw suppliers

6-chloro-1,3-benzodioxole-5-carbaldehyde ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 6-CHLOROPIPERONAL

There total 7 articles about 6-CHLOROPIPERONAL which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

piperonal (120-57-0,30024-74-9) → 6-chloropiperonal (15952-61-1)

Guidance literature:

With trichloroisocyanuric acid; In ethanol; at 50 ℃; for 3h;

DOI:10.1016/j.ejmech.2015.09.009

Reference yield: 78.0%

6-amino-benzo[1,3]dioxole-5-carbaldehyde (23126-68-3) → 6-chloropiperonal (15952-61-1)

Guidance literature:

6-amino-benzo[1,3]dioxole-5-carbaldehyde; With hydrogenchloride; sodium nitrite; In water; for 1h; Cooling with ice;

With copper(l) chloride; at 80 ℃; for 10h; Cooling with ice;

Reference yield: 75.0%

6-chloro-3,4-methylenedioxybenzyl alcohol (2591-25-5) → 5-bromo-6-chloro-benzo[1,3]dioxole (233770-05-3) + 6-chloropiperonal (15952-61-1)

Guidance literature:

With bis(collidine)bromine(I) hexafluorophosphate; In dichloromethane; at 20 ℃; for 10h;

DOI:10.1016/S0040-4039(00)01598-7

upstream raw materials:

piperonal

6-chloro-3,4-methylenedioxybenzyl alcohol

6-nitro-1,3-benzodioxole-5-carbaldehyde

6-amino-benzo[1,3]dioxole-5-carbaldehyde

Downstream raw materials:

C₉H₉ClN₄O₃*C₇H₈O₃S

[1-(6-Chloro-benzo[1,3]dioxol-5-yl)-meth-(E)-ylidene]-(4-methoxy-phenyl)-amine

5-bromo-4-(6-chloro-benzo[1,3]dioxol-5-ylmethyl)-2-cyclohexylmethyl-2H-pyrazole-3-carboxylic acid ethyl ester

Refernces

• 1、 De Melos, Jorge Luiz R.,Torres-Santos, Eduardo Caio,Fai?es, Viviane Dos S.,De Nigris Del Cistia, Catarina,Sant'Anna, Carlos Maurício R.,Rodrigues-Santos, Cláudio Eduardo,Echevarria, Aurea. "Novel 3,4-methylenedioxyde-6-X-benzaldehyde-thiosemicarbazones: Synthesis and antileishmanial effects against Leishmania amazonensis". . p. 409 - 417. Retrieved 2015/09/28.