Technology Process of Jungianol
There total 6 articles about Jungianol which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
sodium hydride; ethanethiol;
In
N,N-dimethyl-formamide;
at 130 ℃;
for 5h;
Inert atmosphere;
DOI:10.1021/acs.joc.5b01071
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: sodium hydroxide / ethanol / 20 °C
2.1: iodine; magnesium / diethyl ether
2.2: 2 h / 20 °C
3.1: triethylamine; methanesulfonyl chloride / tetrahydrofuran / 6 h / 0 - 20 °C
4.1: lithium; ammonia / tetrahydrofuran / 0.17 h / -78 °C
5.1: sodium hydride; ethanethiol / N,N-dimethyl-formamide / 5 h / 130 °C / Inert atmosphere
With
ammonia; iodine; lithium; sodium hydride; magnesium; methanesulfonyl chloride; triethylamine; ethanethiol; sodium hydroxide;
In
tetrahydrofuran; diethyl ether; ethanol; N,N-dimethyl-formamide;
1.1: |Aldol Condensation;
DOI:10.1021/acs.joc.5b01071
- Guidance literature:
-
Multi-step reaction with 3 steps
1: triethylamine; methanesulfonyl chloride / tetrahydrofuran / 6 h / 0 - 20 °C
2: lithium; ammonia / tetrahydrofuran / 0.17 h / -78 °C
3: sodium hydride; ethanethiol / N,N-dimethyl-formamide / 5 h / 130 °C / Inert atmosphere
With
ammonia; lithium; sodium hydride; methanesulfonyl chloride; triethylamine; ethanethiol;
In
tetrahydrofuran; N,N-dimethyl-formamide;
DOI:10.1021/acs.joc.5b01071
