GEA 995

Base Information

• Chemical Name: GEA 995
• CAS No.: 80691-92-5
• Molecular Formula: C₁₄H₂₀ClNO
• Molecular Weight: 253.772
• Mol file: 80691-92-5.mol

Synonyms:

Chemical Property of GEA 995

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of GEA 995

There total 3 articles about GEA 995 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

6-(4-chlorophenyl)-5,5-dimethyl-2,4-hexandione (80692-04-2) → 5-amino-1-(4-chlorophenyl)-2,2-dimethyl-3-hexanone (80691-92-5)

Guidance literature:

With ammonium acetate; 3 A molecular sieve; sodium cyanoborohydride; acetic acid; In methanol; for 30h; Ambient temperature;

Reference yield:

3-(4-chlorophenyl)-2,2-dimethylpropanoic acid methyl ester (14305-27-2) → 5-amino-1-(4-chlorophenyl)-2,2-dimethyl-3-hexanone (80691-92-5)

Guidance literature:

Multi-step reaction with 3 steps

1: 33 percent / hexamethylphosphoric acid triamide / 4 h / 80 °C

2: 25.2 percent / sodium hydride / diethyl ether / 5.5 h / Heating

3: ammonium acetate, sodium cyanoborohydride, acetic acid, molecular sieves (3 Angstroem) / methanol / 30 h / Ambient temperature

With ammonium acetate; 3 A molecular sieve; sodium hydride; sodium cyanoborohydride; acetic acid; In methanol; N,N,N,N,N,N-hexamethylphosphoric triamide; diethyl ether;

Reference yield:

4-(4-chlorophenyl)-3,3-dimethyl-2-butanone (80703-89-5) → 5-amino-1-(4-chlorophenyl)-2,2-dimethyl-3-hexanone (80691-92-5)

Guidance literature:

Multi-step reaction with 2 steps

1: 25.2 percent / sodium hydride / diethyl ether / 5.5 h / Heating

2: ammonium acetate, sodium cyanoborohydride, acetic acid, molecular sieves (3 Angstroem) / methanol / 30 h / Ambient temperature

With ammonium acetate; 3 A molecular sieve; sodium hydride; sodium cyanoborohydride; acetic acid; In methanol; diethyl ether;

upstream raw materials:

6-(4-chlorophenyl)-5,5-dimethyl-2,4-hexandione

3-(4-chlorophenyl)-2,2-dimethylpropanoic acid methyl ester

4-(4-chlorophenyl)-3,3-dimethyl-2-butanone

Refernces