3-Ethylindole

Base Information

• Chemical Name: 3-Ethylindole
• CAS No.: 1484-19-1
• Molecular Formula: C10H11N
• Molecular Weight: 145.204
• Hs Code.: 2933990090
• Mol file: 1484-19-1.mol

Synonyms:β-Ethylindole;3-Ethylindole;NSC 289350;Indole, 3-ethyl- (6CI,7CI,8CI);3-Ethyl-1H-indole;

Chemical Property of 3-Ethylindole

Chemical Property:

• Vapor Pressure: 0.00592mmHg at 25°C
• Melting Point: 37°C
• Refractive Index: 1.632
• Boiling Point: 281.9 °C at 760 mmHg
• PKA: 17.30±0.30(Predicted)
• Flash Point: 119.9 °C
• PSA: 15.79000
• Density: 1.078 g/cm³
• LogP: 2.73030
• Storage Temp.: Keep in dark place,Sealed in dry,Room Temperature

Purity/Quality:

98%min ^*data from raw suppliers

3-Ethyl-1H-indole ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 3-Ethyl-1H-indole is used in the process for producing methanol.

Technology Process of 3-Ethylindole

There total 76 articles about 3-Ethylindole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

3-acetylindole (703-80-0) → 3-ethyl-1H-indole (1484-19-1)

Guidance literature:

With palladium 10% on activated carbon; water; hydrazine hydrate; In ethanol; at 100 ℃; for 24h; Reagent/catalyst;

DOI:10.1016/j.tetlet.2019.151447

Reference yield: 99.0%

indole (120-72-9) + ethyl vinyl ether (109-92-2,25104-37-4) → 3-ethyl-1H-indole (1484-19-1)

Guidance literature:

With indium(III) chloride; In tetrahydrofuran; at 70 ℃; for 12h; Reagent/catalyst; Solvent; Temperature; Schlenk technique;

Reference yield: 97.0%

2-(2-nitrophenyl)butanenitrile → 3-ethyl-1H-indole (1484-19-1)

Guidance literature:

With hydrogen; at 20 ℃; for 24h; under 760.051 Torr; Schlenk technique;

DOI:10.1021/acs.orglett.6b02659

upstream raw materials:

3-acetylindole

ethanol

sodium ethanolate

Indole-2-carboxylic acid

Downstream raw materials:

2-sec-butyl-cyclohexylamine

N-(2-propionylphenyl)formamide

3-ethyl-1-(phenylsulfonyl)-1H-indole

1-<(p-methoxyphenyl)sulfonyl>-3-ethylindole

Refernces

• 1、 Fitzpatrick,Hiser. "-". . p. 1703. Retrieved 1957.
• 2、 Bremer, Paul T.,Xue, Song,Janda, Kim D.. "Picolinic acids as β-exosite inhibitors of botulinum neurotoxin A light chain". . p. 12521 - 12524. Retrieved 2016.
• 3、 Watanabe, Yoshihisa,Yamamoto, Michihiro,Shim, Sang Chul,Miyanaga, Sogo,Mitsudo, Take-aki. "THE TRANSITION METAL-CATALYZED N-HETEROCYCLIZATION. THE RHODIUM-CATALYZED SYNTHESIS OF INDOLES". . p. 603 - 604. Retrieved 1980.
• 4、 Boldrini et al.. "-". . p. 359. Retrieved 1974.
• 5、 -. "Compound containing indole ring structure, preparation method and application of compound, and bactericide". Paragraph 0080; 0085; 0086; 0087. . Retrieved 2021/07/31.
• 6、 Devi, Manju,Jadhav, Amol P.,Singh, Ravi P.. "KOH-mediated stereoselective alkylation of 3-bromooxindoles for the synthesis of 3,3′-disubstituted oxindoles with two contiguous all carbon quaternary centres". supporting information. p. 8445 - 8448. Retrieved 2021/05/25.