1,3-Dioxolo[4,5-h]isoquinoline(8CI,9CI)

Base Information

• Chemical Name: 1,3-Dioxolo[4,5-h]isoquinoline(8CI,9CI)
• CAS No.: 234-17-3
• Molecular Formula: C10H7 N O2
• Molecular Weight: 173.17
• Mol file: 234-17-3.mol

Synonyms:7,8-(Methylenedioxy)isoquinoline;7,8-[Methylenebis(oxy)]isoquinoline

Chemical Property of 1,3-Dioxolo[4,5-h]isoquinoline(8CI,9CI)

Chemical Property:

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s): A poison by ingestion.
• Hazard Codes: A poison
• Safety Statements: A poison by ingestion. When heated to decomposition it emits toxic vapors of NOx.:;"> x." target="_blank">A poison by ingestion. When heated to decomposition it emits toxic vapors of NOx.:

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1,3-Dioxolo[4,5-h]isoquinoline(8CI,9CI)

There total 5 articles about 1,3-Dioxolo[4,5-h]isoquinoline(8CI,9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.0%

6,7,8,9-tetrahydro-[1,3]dioxolo[4,5-h]isoquinolin-6-ol (390802-20-7) → 7,8-methylene-dioxyisoquinoline (234-17-3)

Guidance literature:

6,7,8,9-tetrahydro-[1,3]dioxolo[4,5-h]isoquinolin-6-ol; With N-Bromosuccinimide;

With hydrogenchloride; In ethanol;

DOI:10.1248/bpb.24.1277

Reference yield:

[1-Benzo[1,3]dioxol-4-yl-meth-(Z)-ylidene]-(2,2-dimethoxy-ethyl)-amine → 7,8-methylene-dioxyisoquinoline (234-17-3)

Guidance literature:

Multi-step reaction with 3 steps

1.1: 90 percent / H₂ / Pd/C

2.1: 58 percent / aq. HCl

3.1: N-bromosuccinimide

3.2: 67 percent / aq. HCl / ethanol

With hydrogenchloride; N-Bromosuccinimide; hydrogen; palladium on activated charcoal;

DOI:10.1248/bpb.24.1277

Reference yield:

2H-benzo[d]1,3-dioxolane-4-carbaldehyde (7797-83-3) → 7,8-methylene-dioxyisoquinoline (234-17-3)

Guidance literature:

Multi-step reaction with 4 steps

1.1: Heating

2.1: 90 percent / H₂ / Pd/C

3.1: 58 percent / aq. HCl

4.1: N-bromosuccinimide

4.2: 67 percent / aq. HCl / ethanol

With hydrogenchloride; N-Bromosuccinimide; hydrogen; palladium on activated charcoal;

DOI:10.1248/bpb.24.1277

upstream raw materials:

6,7,8,9-tetrahydro-[1,3]dioxolo[4,5-h]isoquinolin-6-ol

2H-benzo[d]1,3-dioxolane-4-carbaldehyde

2,3-methylenedioxybenzylaminoacetaldehyde dimethylacetal

Downstream raw materials:

8-(3,4-dimethoxy-phenethyl)-[1,3]dioxolo[4,5-h]isoquinolinium; bromide

Refernces