1-[AMINO(PHENYL)METHYL]-2-NAPHTHOL HYDROCHLORIDE

Base Information

• Chemical Name: 1-[AMINO(PHENYL)METHYL]-2-NAPHTHOL HYDROCHLORIDE
• CAS No.: 481-82-3
• Molecular Formula: C17H15 N O
• Molecular Weight: 249.312
• Mol file: 481-82-3.mol

Synonyms:2-Naphthol,1-(a-aminobenzyl)- (6CI,7CI,8CI); (?à)-1-(a-Aminobenzyl)-2-naphthol; 1-(a-Aminobenzyl)-2-naphthol;1-[Amino(phenyl)methyl]-2-naphthalenol; 2-Hydroxy-a-phenyl-1-naphthalenemethanamine; Betti's base; NSC37611

Chemical Property of 1-[AMINO(PHENYL)METHYL]-2-NAPHTHOL HYDROCHLORIDE

Chemical Property:

• Vapor Pressure: 9.38E-09mmHg at 25°C
• Melting Point: 173-175 °C(Solv: ethanol (64-17-5))
• Boiling Point: 451.1°Cat760mmHg
• PKA: 9.07±0.50(Predicted)
• Flash Point: 226.6°C
• PSA: 46.25000
• Density: 1.211g/cm³
• LogP: 5.09580

Purity/Quality:

99% ^*data from raw suppliers

1-(Amino(phenyl)methyl)naphthalen-2-olhydrochloride 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Uses: 2-Naphthalenol, 1-(aminophenylmethyl)- can be used as organic synthesis intermediate and pharmaceutical intermediate, mainly used in laboratory research and development process and chemical production process.

Technology Process of 1-[AMINO(PHENYL)METHYL]-2-NAPHTHOL HYDROCHLORIDE

There total 18 articles about 1-[AMINO(PHENYL)METHYL]-2-NAPHTHOL HYDROCHLORIDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.0%

benzaldehyde (100-52-7) + β-naphthol (135-19-3) → 1-(α-aminobenzyl)-2-naphthol (481-82-3)

Guidance literature:

With ammonia; In ethanol; water; at 20 ℃; for 2h;

DOI:10.1016/j.tet.2014.06.052

Reference yield:

hydrogenchloride (7647-01-0,15364-23-5) + 1-(α-benzylidenamino-benzyl)-[2]naphthol (53983-76-9) → 1-(α-aminobenzyl)-2-naphthol (481-82-3) + benzaldehyde (100-52-7)

Guidance literature:

Reference yield:

hydrogenchloride (7647-01-0,15364-23-5) + N-[(2-hydroxy-[1]naphthyl)-phenyl-methyl]-glucopyranosylamine → glucose (50-99-7,59-23-4,921-60-8,1949-88-8,1990-29-0,2152-76-3,2595-97-3,2595-98-4,3458-28-4,4205-23-6,5934-56-5,5978-95-0,5987-68-8,6027-89-0,6038-51-3,7635-11-2,10030-80-5,15572-79-9,19163-87-2,23567-25-1,26566-61-0,30077-17-9,31103-86-3,39665-52-6,40866-07-7,58367-01-4,58407-05-9,58407-06-0,83198-69-0,83198-70-3,83198-71-4,93780-23-5,145920-48-5) + 1-(α-aminobenzyl)-2-naphthol (481-82-3)

Guidance literature:

glucose derivative of levorotatory 2-oxy-1-<α-amino-benzyl>-naphthalene;

upstream raw materials:

hydrogenchloride

1-(α-benzylidenamino-benzyl)-[2]naphthol

1-(Phenyl-{[1-phenyl-meth-(E)-ylidene]-amino}-methyl)-naphthalen-2-ol

benzaldehyde

Downstream raw materials:

1-[phenyl(piperidin-1-yl)methyl]naphthalen-2-ol

1-(phenyl(morpholin-4-yl)methyl)naphthalen-2-ol

1-(α-piperonylidenamino-benzyl)-[2]naphthol

1-(α-benzylidenamino-benzyl)-[2]naphthol

Refernces

• 1、 -. "Optically pure 1 - (α-aminobenzyl) - 2-naphthol preparation method". . . Retrieved 2017/04/11.
• 2、 Bian, Guangling,Yang, Shiwei,Huang, Huayin,Song, Ling. "A new method for the synthesis of enantiomerically pure Betti base". . p. 899 - 902. Retrieved 2013/05/22.