Pregn-4-ene-3,20-dione,11,17-dihydroxy-, (11a)-

Base Information

• Chemical Name: Pregn-4-ene-3,20-dione,11,17-dihydroxy-, (11a)-
• CAS No.: 603-98-5
• Molecular Formula: C21H30 O4
• Molecular Weight: 346.467
• Mol file: 603-98-5.mol

Synonyms:Pregn-4-ene-3,20-dione,11a,17-dihydroxy- (8CI); Progesterone, 11a,17-dihydroxy-(6CI); 11a,17-Dihydroxyprogesterone; 11a,17a-Dihydroxy-4-pregnene-3,20-dione; 11a,17a-Dihydroxyprogesterone;NSC 48979; NSC 9730

Chemical Property of Pregn-4-ene-3,20-dione,11,17-dihydroxy-, (11a)-

Chemical Property:

• Melting Point: 216-218 °C
• Boiling Point: 523.9°Cat760mmHg
• PKA: 12.86±0.70(Predicted)
• Flash Point: 284.7°C
• PSA: 74.60000
• Density: 1.21g/cm³
• LogP: 2.80920

Purity/Quality:

99% ^*data from raw suppliers

(11α)-11,17-Dihydroxypregn-4-ene-3,20-dione ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: (11α)-11,17-Dihydroxypregn-4-ene-3,20-dione is a dihydroxyl product of progesterone by three species of the genus Humicola;Also, it is derived from 11α-Hydroxy Progesterone (H952335), which is a Progesterone (P755900) metabolite.

Technology Process of Pregn-4-ene-3,20-dione,11,17-dihydroxy-, (11a)-

There total 5 articles about Pregn-4-ene-3,20-dione,11,17-dihydroxy-, (11a)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.6%

C21H29BrO4 → Hydrocortison (603-98-5,641-77-0,4076-89-5,6148-30-7)

Guidance literature:

With 2,2'-azobis(2-methylpropionamidine) hydrochloride; hypophosphorous acid; sodium carbonate; In water; isopropyl alcohol; at 80 ℃; Green chemistry;

Reference yield:

→ 11β,17α-Dihydroxy-pregnen-(4)-dion-(3,20) (603-98-5,641-77-0,4076-89-5,6148-30-7)

Guidance literature:

11β-Hydroxy-3,20-dioxo-pregnen-(4), biochem. Oxidation mit Trichoderma viride Kulturen;

Reference yield:

→ 11α,17α-Dihydroxy-pregn-4-en-3,20-dion (603-98-5,641-77-0,4076-89-5,6148-30-7)

Guidance literature:

Acetat VIII, Verseifung;

Downstream raw materials:

17-acetoxy-pregna-4,9⁽¹¹⁾-diene-3,20-dione

pregna-4,9⁽¹¹⁾-diene-3,20-dione-17-hydroxy-21-methyl

Cortisone acetate

11α,17α-dihydroxyprogesterone-21-acetate

Refernces

• 1、 Sallam,el-Refai,el-Kady. "Transformation of progesterone by Aspergillus niger 100 and Rhizopus nigricans REF, 129.". . p. 1239 - 1242. Retrieved 2007/10/06.