1-(2-Bromoethoxy)-4-chlorobenzene

Base Information

• Chemical Name: 1-(2-Bromoethoxy)-4-chlorobenzene
• CAS No.: 2033-76-3
• Molecular Formula: C8H8BrClO
• Molecular Weight: 235.508
• Hs Code.: 29093090
• European Community (EC) Number: 217-994-9
• NSC Number: 404198
• UNII: CL9TNF9G7X
• DSSTox Substance ID: DTXSID20174237
• Nikkaji Number: J265.469E
• Mol file: 2033-76-3.mol

Synonyms:1-(2-Bromoethoxy)-4-chlorobenzene;2033-76-3;Benzene, 1-(2-bromoethoxy)-4-chloro-;4-Chlorophenyl 2-bromoethyl ether;C8H8BrClO;2-bromoethyl 4-chlorophenyl ether;2-(4-chlorophenoxy)ethyl bromide;1-Bromo-2-(4-chlorophenoxy)ethane;EINECS 217-994-9;NSC-404198;AI3-02510;MFCD00000617;NSC404198;O(CCBr)c1ccc(Cl)cc1;CL9TNF9G7X;p-chlorophenoxyethyl bromide;4-Chlorophenoxyethyl bromide;beta-Bromo-p-chlorophenetole;beta-Bromo-4-chlorophenetole;SCHEMBL689019;2-(p-Chlorophenoxy)ethyl bromide;4-chlorphenyl 2-bromoethyl ether;DTXSID20174237;4-(2-Bromoethoxy)-1-chlorobenzene;STK499477;1-(2-bromo-ethoxy)-4-chloro-benzene;AKOS000199793;AB90274;AM86740;NSC 404198;4-Chlorophenyl 2-bromoethyl ether, 98%;AS-11460;B4298;CS-0117207;FT-0633984;EN300-08149;A856751;J-013226;Z56926557;Ethyl4-(4-aminophenyl)tetrahydro-1(2H)-pyrazinecarboxylate

Chemical Property of 1-(2-Bromoethoxy)-4-chlorobenzene

Chemical Property:

• Appearance/Colour: Clear liquid or low melting solid
• Vapor Pressure: 0.00329mmHg at 25°C
• Melting Point: 40-42 °C(lit.)
• Refractive Index: 1.5685 (589.3 nm 20℃)
• Boiling Point: 292 °C at 760 mmHg
• Flash Point: 121.5 °C
• PSA: 9.23000
• Density: 1.518 g/cm³
• LogP: 3.11370
• Storage Temp.: Sealed in dry,Room Temperature
• Solubility.: soluble in Methanol
• XLogP3: 3.3
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 3
• Exact Mass: 233.94471
• Heavy Atom Count: 11
• Complexity: 102

Purity/Quality:

98%,99%, ^*data from raw suppliers

1-(2-Bromoethoxy)-4-chlorobenzene ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xn
• Hazard Codes: Xn
• Statements: 36/37/38-20/22
• Safety Statements: 36/37/39-26-24/25

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Canonical SMILES: C1=CC(=CC=C1OCCBr)Cl
• Uses: 4-Chlorophenyl 2-bromoethyl ether may be used in chemical synthesis.

Technology Process of 1-(2-Bromoethoxy)-4-chlorobenzene

There total 4 articles about 1-(2-Bromoethoxy)-4-chlorobenzene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.2%

4-chloro-phenol (106-48-9,82344-39-6) + ethylene dibromide (106-93-4) → 1-(2-bromoethoxy)-4-chlorobenzene (2033-76-3)

Guidance literature:

With sodium hydroxide; In water; for 12h; Reflux;

Reference yield: 52.0%

potassium 4-chlorophenoxide (1121-74-0) + ethylene dibromide (106-93-4) → 1-(2-bromoethoxy)-4-chlorobenzene (2033-76-3)

Guidance literature:

With tetra-(n-butyl)ammonium iodide; In acetonitrile; for 24h; Heating;

DOI:10.1016/j.bmc.2005.01.014

Reference yield: 33.0%

→ 1-(2-bromoethoxy)-4-chlorobenzene (2033-76-3)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; at 100 ℃; for 16h; Inert atmosphere;

upstream raw materials:

4-chloro-phenol

ethylene dibromide

potassium 4-chlorophenoxide

diisopropyl (E)-azodicarboxylate

Downstream raw materials:

1-[2-(4-chloro-phenoxy)-ethyl]-pyridinium; bromide

2-[2-(4-chloro-phenoxy)-ethylamino]-ethanol

[2-(4-chloro-phenoxy)-ethyl]-bis-(2-hydroxy-ethyl)-amine

E-1-(2,4-dichlorophenyl)-1-(2-(4-chlorophenoxy)-ethoxy)-2-(imidazol-1-yl)-propene nitrate

Refernces

• 1、 Carbonara, Giuseppe,Fracchiolla, Giuseppe,Loiodice, Fulvio,Tortorella, Paolo,Conte-Camerino, Diana,De Luca, Annamaria,Liantonio, Antonella. "Carboxylic acids and skeletal muscle chloride channel conductance: Effects on the biological activity induced by the introduction of an aryloxyalkyl group α to the carboxylic function of 4-chloro-phenoxyacetic acid". . p. 749 - 754. Retrieved 2001.
• 2、 Khalafi-Nezhad,Soltani Rad,Mohabatkar,Asrari,Hemmateenejad. "Design, synthesis, antibacterial and QSAR studies of benzimidazole and imidazole chloroaryloxyalkyl derivatives". . p. 1931 - 1938. Retrieved 2005.
• 3、 -. "Dofetilide-d3 drug and preparation method thereof". Paragraph 0056-0058. . Retrieved 2020/07/21.
• 4、 Sniecikowska, Joanna,Gluch-Lutwin, Monika,Bucki, Adam,Wi?ckowska, Anna,Siwek, Agata,Jastrzebska-Wiesek, Magdalena,Partyka, Anna,Wilczyńska, Daria,Pytka, Karolina,Latacz, Gniewomir,Przejczowska-Pomierny, Katarzyna,Wyska, El?bieta,Weso?owska, Anna,Paw?owski, Maciej,Newman-Tancredi, Adrian,Kolaczkowski, Marcin. "Discovery of Novel pERK1/2- or β-Arrestin-Preferring 5-HT1AReceptor-Biased Agonists: Diversified Therapeutic-like versus Side Effect Profile". supporting information. p. 10946 - 10971. Retrieved 2020/11/09.