2-Amino-4-(4-bromophenyl)thiazole

Base Information

• Chemical Name: 2-Amino-4-(4-bromophenyl)thiazole
• CAS No.: 2103-94-8
• Molecular Formula: C9H7BrN2S
• Molecular Weight: 255.138
• Hs Code.: 29341000
• Mol file: 2103-94-8.mol

Synonyms:Thiazole,2-amino-4-(p-bromophenyl)- (6CI,7CI,8CI);2-Amino-4-(p-bromophenyl)thiazole;4-(4-Bromophenyl)-1,3-thiazol-2-amine;4-(4-Bromophenyl)-1,3-thiazol-2-ylamine;4-(4-Bromophenyl)-2-thiazolamine;4-(4'-Bromophenyl)-2-aminothiazole;4-(p-Bromophenyl)-2-aminothiazole;

Chemical Property of 2-Amino-4-(4-bromophenyl)thiazole

Chemical Property:

• Appearance/Colour: beige to yellow powder
• Vapor Pressure: 5.8E-07mmHg at 25°C
• Melting Point: 183-187 °C(lit.)
• Refractive Index: 1.684
• Boiling Point: 410.943 °C at 760 mmHg
• PKA: 3.95±0.10(Predicted)
• Flash Point: 202.331 °C
• PSA: 67.15000
• Density: 1.637 g/cm³
• LogP: 3.73600
• Water Solubility.: Insoluble

Purity/Quality:

99% ^*data from raw suppliers

4-(4-Bromophenyl)-1,3-thiazol-2-amine ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36-37/39

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-Amino-4-(4-bromophenyl)thiazole

There total 21 articles about 2-Amino-4-(4-bromophenyl)thiazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

thiourea (17356-08-0) + para-bromophenacyl bromide (99-73-0,132309-76-3) → 4-(4-bromophenyl)-1,3-thiazol-2-amine (2103-94-8)

Guidance literature:

With diammonium phosphate; In ethanol; water; at 20 ℃; for 0.5h;

DOI:10.1080/00397910802219155

Reference yield: 99.0%

para-bromoacetophenone (99-90-1) + thiourea (17356-08-0) → 4-(4-bromophenyl)-1,3-thiazol-2-amine (2103-94-8)

Guidance literature:

With iodine; at 130 - 150 ℃; for 0.166667h; Neat (no solvent); Microwave irradiation;

DOI:10.1016/j.tetlet.2012.05.093

Reference yield: 96.0%

p-bromophenylacetaldehyde (27200-79-9) + thiourea (17356-08-0) → 4-(4-bromophenyl)-1,3-thiazol-2-amine (2103-94-8)

Guidance literature:

With iodine; In dimethyl sulfoxide; at 80 ℃; for 0.0166667h; Green chemistry;

DOI:10.1007/s11164-021-04630-4

upstream raw materials:

para-bromoacetophenone

thiourea

para-bromophenacyl bromide

α-tosyloxy-4-bromoacetophenone

Downstream raw materials:

4-(4-bromo-phenyl)-5-thiocyanato-thiazol-2-ylamine

3-(4-bromo-phenyl)-6-thiophen-2-yl-imidazo[2,1-b]thiazole

3-(4-bromo-phenyl)-pyrido[2,3-d]thiazolo[3,2-a]pyrimidin-5-one

(1H-benzoimidazol-2-ylmethyl)-[4-(4-bromo-phenyl)-thiazol-2-yl]-amine

Refernces

• 1、 Akbarzadeh, Elaheh,Shockravi, Abbas,Vatanpour, Vahid. "Efficient thiazole-based polyimines as selective and reversible chemical absorbents for CO2 capture and separation: Synthesis, characterization and application". . . Retrieved 2019.
• 2、 Kalhor, Mehdi,Zarnegar, Zohre. "1-Methylimidazolium ionic liquid supported on Ni@zeolite-Y: fabrication and performance as a novel multi-functional nanocatalyst for one-pot synthesis of 2-aminothiazoles and 2-aryl benzimidazoles". . p. 519 - 540. Retrieved 2021/12/03.
• 3、 Ujwaldev, Sankuviruthiyil M.,Harry, Nissy Ann,Neetha, Mohan,Anilkumar, Gopinathan. "Novel synthesis of 2-Aminothiazoles via Fe(III)-Iodine-catalyzed Hantzsch-type condensation". supporting information. p. 646 - 653. Retrieved 2020/10/20.