dichlorisone

Base Information

• Chemical Name: dichlorisone
• CAS No.: 7008-26-6
• Molecular Formula: C21H26 Cl2 O4
• Molecular Weight: 413.341
• Mol file: 7008-26-6.mol

Synonyms:Pregna-1,4-diene-3,20-dione,9,11b-dichloro-17,21-dihydroxy-(6CI,7CI,8CI); 9a,11b-Dichloro-17a,21-dihydroxypregna-1,4-diene-3,20-dione;Dichlorisone

Chemical Property of dichlorisone

Chemical Property:

• Vapor Pressure: 3.42E-16mmHg at 25°C
• Melting Point: 238-241 °C (decomp)(Solv: acetone (67-64-1))
• Boiling Point: 586.4°C at 760 mmHg
• PKA: 11.99±0.70(Predicted)
• Flash Point: 308.4°C
• PSA: 74.60000
• Density: 1.37g/cm³
• LogP: 3.16550

Purity/Quality:

98%Min ^*data from raw suppliers

Dichlorisone ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: Dichlorisone is a 9α,11β-dichloro corticoid. Dichlorisone has anti-antiinflammatory potency. Dichlorisone could be modifed to be used as glucocorticoid receptor agonists as well as a P-glycoprotein inhibitor.

Technology Process of dichlorisone

There total 4 articles about dichlorisone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

dichlorisone 21-acetate (79-61-8) → Dichlorisone (7008-26-6)

Guidance literature:

With perchloric acid;

DOI:10.1021/ja01518a045

Reference yield:

pregna-1,4,9(11)-triene-17α,21-diol-3,20-dione 21-acetate (4380-55-6) → Dichlorisone (7008-26-6)

Guidance literature:

Multi-step reaction with 2 steps

1: acetic acid; THF; LiCl; HCl

2: methanol.HClO₄

With tetrahydrofuran; hydrogenchloride; perchloric acid; acetic acid; lithium chloride;

DOI:10.1021/ja01518a045

Reference yield:

→ 9α,11β-Dichlor-17α,21-dihydroxy-3,20-dioxo-pregnadien-(1,4) (7008-26-6)

Guidance literature:

Trien XXXI, Cl2;

upstream raw materials:

dichlorisone 21-acetate

pregna-1,4,9(11)-triene-17α,21-diol-3,20-dione 21-acetate