Tetrahydro-2,2,6-trimethyl-2H-pyran

Base Information

• Chemical Name: Tetrahydro-2,2,6-trimethyl-2H-pyran
• CAS No.: 32700-63-3
• Molecular Formula: C8H16 O
• Molecular Weight: 128.214
• Hs Code.: 2932999099
• European Community (EC) Number: 251-163-1
• DSSTox Substance ID: DTXSID10954383
• Nikkaji Number: J319.422A
• Mol file: 32700-63-3.mol

Synonyms:2,2,6-trimethyloxane;Tetrahydro-2,2,6-trimethyl-2H-pyran;32700-63-3;EINECS 251-163-1;2,2,6-Trimethyltetrahydro-2H-pyran;trimethyltetrahydropyran;SCHEMBL16877083;DTXSID10954383;AKOS006327493

Chemical Property of Tetrahydro-2,2,6-trimethyl-2H-pyran

Chemical Property:

• Vapor Pressure: 10.8mmHg at 25°C
• Boiling Point: 132.6°Cat760mmHg
• Flash Point: 29.3°C
• PSA: 9.23000
• Density: 0.822g/cm³
• LogP: 2.35400
• XLogP3: 2
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 0
• Exact Mass: 128.120115130
• Heavy Atom Count: 9
• Complexity: 96.7

Purity/Quality:

99% ^*data from raw suppliers

TETRAHYDRO-2,2,6-TRIMETHYL-2H-PYRAN 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1CCCC(O1)(C)C

Technology Process of Tetrahydro-2,2,6-trimethyl-2H-pyran

There total 17 articles about Tetrahydro-2,2,6-trimethyl-2H-pyran which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

6-methylhept-5-en-2-ol (4630-06-2,1569-60-4) → 2,2,6-Trimethyltetrahydropyran (32700-63-3)

Guidance literature:

tris(triphenylphosphine)ruthenium(II) chloride; In water; at 185 ℃; under 7600 Torr; microwave irradiation;

DOI:10.1246/cl.2005.664

Reference yield: 8.0%

6-methylhept-5-en-2-ol (4630-06-2,1569-60-4) → 2,2,6-Trimethyltetrahydropyran (32700-63-3) + 6-iodo-6-methylheptan-2-ol

Guidance literature:

With iodine; HSiPh₃; In dichloromethane; at 20 ℃; for 12h;

DOI:10.1021/acs.orglett.5b01797

Reference yield:

N-<(6-Methyl-5-heptenyl)-2-oxy>pyridine-2(1H)-thione (171557-71-4) → 2,2,6-Trimethyltetrahydropyran (32700-63-3) + trans-2-(2'-Propyl)-5-methyltetrahydrofuran + cis-2-(2'-Propyl)-5-methyltetrahydrofuran

Guidance literature:

With 2-Naphthalenethiol; In benzene-d6; at 15 ℃; for 0.0833333h; Yield given. Yields of byproduct given. Title compound not separated from byproducts; Irradiation;

DOI:10.1021/jo00126a021

upstream raw materials:

6-methylhept-5-en-2-ol

6-methylheptan-2,6-diol

N-<(6-Methyl-5-heptenyl)-2-oxy>pyridine-2(1H)-thione

6-Methyl-hept-5-en-2-on

Downstream raw materials:

6-methylheptan-2-one

Refernces

• 1、 Zhu, Xuehua,Li, Guoyao,Xu, Fan,Zhang, Yong,Xue, Mingqiang,Shen, Qi. "Investigation and mechanistic study into intramolecular hydroalkoxylation of unactivated alkenols catalyzed by cationic lanthanide complexes". . p. 1451 - 1458. Retrieved 2017/02/19.
• 2、 Catti,Tiefenbacher. "Intramolecular hydroalkoxylation catalyzed inside a self-assembled cavity of an enzyme-like host structure". supporting information. p. 892 - 894. Retrieved 2015/02/05.