2-methoxypropiophenone

Base Information

• Chemical Name: 2-methoxypropiophenone
• CAS No.: 5561-92-2
• Molecular Formula: C10H12 O2
• Molecular Weight: 164.204
• Hs Code.: 2914509090
• Mol file: 5561-92-2.mol

Synonyms:Propiophenone,2'-methoxy- (7CI,8CI); 1-(2-Methoxyphenyl)-1-propanone;2'-Methoxypropiophenone; Ethyl 2-methoxyphenyl ketone; Ethyl guaiacyl ketone;Guaiacyl ethyl ketone; NSC 406919; o-Methoxypropiophenone

Chemical Property of 2-methoxypropiophenone

Chemical Property:

• Boiling Point: 247°Cat760mmHg
• Flash Point: 100.3°C
• PSA: 26.30000
• Density: 1.016g/cm³
• LogP: 2.28790

Purity/Quality:

99%, ^*data from raw suppliers

1-(2-methoxyphenyl)propan-1-one ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-methoxypropiophenone

There total 25 articles about 2-methoxypropiophenone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

1-(o-methoxyphenyl)-1-propanol (7452-01-9) → 1-(2-methoxyphenyl)propan-1-one (5561-92-2)

Guidance literature:

With 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; iron(II) nitrate nonahydrate; oxygen; sodium chloride; In toluene; at 20 ℃; under 760.051 Torr;

DOI:10.1021/acs.orglett.8b00612

Reference yield: 93.0%

1-(2-Hydroxy-phenyl)-propan-1-on (610-99-1) + methyl iodide (74-88-4) → 1-(2-methoxyphenyl)propan-1-one (5561-92-2)

Guidance literature:

With caesium carbonate; In acetone; at 20 ℃;

Reference yield: 85.37%

propionyl chloride (79-03-8) + methoxybenzene (100-66-3) → 1-(2-methoxyphenyl)propan-1-one (5561-92-2) + 4-Methoxypropiophenone (121-97-1)

Guidance literature:

With zeolite H-beta; at 69.85 ℃; for 2h; Further Variations:; Temperatures; Reagents; Product distribution;

upstream raw materials:

ethylmagnesium iodide

2-methoxy-benzonitrile

2-methoxybenzamide

ethylmagnesium bromide

Downstream raw materials:

1-(2-Hydroxy-phenyl)-propan-1-on

2-Bromo-2'-methoxypropiophenone

2-<1-Ethyl-hepten-(1)-yl>-anisol

2-(1-ethyl-propenyl)-anisole

Refernces

• 1、 An, Sejin,Moon, Da Yoon,Park, Bong Ser. "Solvent free, light induced 1,2-bromine shift reaction of α-bromo ketones". . p. 6922 - 6928. Retrieved 2018/10/24.
• 2、 Tran, Phuong Hoang,Nguyen, Hai Truong,Hansen, Poul Erik,Le, Thach Ngoc. "An efficient and green method for regio- and chemo-selective Friedel-Crafts acylations using a deep eutectic solvent ([CholineCl][ZnCl2]3)". . p. 37031 - 37038. Retrieved 2016/05/24.