2-Pyridinol-1-oxide

Base Information

• Chemical Name: 2-Pyridinol-1-oxide
• CAS No.: 13161-30-3
• Molecular Formula: C5H5NO2
• Molecular Weight: 111.1
• Hs Code.: 29333990
• Mol file: 13161-30-3.mol

Synonyms:2-Hydroxypyridine1-oxide;2-Hydroxypyridine N-oxide;2-Pyridinol-N-oxide;NSC 406972;Oxypyrion;

Chemical Property of 2-Pyridinol-1-oxide

Chemical Property:

• Appearance/Colour: Weight 20% solution in water
• Vapor Pressure: 0mmHg at 25°C
• Melting Point: 149-152 °C
• Refractive Index: 1.554
• Boiling Point: 387.694 °C at 760 mmHg
• PKA: pK1:-0.62;pK2:5.97(0) (25°C)
• Flash Point: 188.271 °C
• PSA: 45.69000
• Density: 1.431 g/cm³
• LogP: 0.82070
• Storage Temp.: Store at RT.
• Solubility.: Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly), Water (Slightly)
• Water Solubility.: 331g/L

Purity/Quality:

98%, ^*data from raw suppliers

2-Hydroxypyridine N-Oxide ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi,Xn
• Hazard Codes: Xi,Xn
• Statements: 36/37/38-40
• Safety Statements: 26-36-22

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 2-Pyridinol 1-oxide can be used:???? To fabricate gold electrodes for the electrochemical determination of europium using cyclic voltammetry.???????? To prepare polymeric nickel (II) complex of 2-hydroxypyridine-N-oxide.In the synthesis of 1-methoxypyrid-4-one in the presence of sodium methoxide and methyl toluene-9-sulphonate.

Technology Process of 2-Pyridinol-1-oxide

There total 17 articles about 2-Pyridinol-1-oxide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

2-hydroxypyridin (142-08-5) → 2-hydroxy-pyridine N-oxide (13161-30-3)

Guidance literature:

With titanium silicate; dihydrogen peroxide; In methanol; at 60 ℃; for 25h;

Reference yield: 90.0%

2,2-dimethyl-4-(2-oxo-2H-pyrid-1-yl)oxy-2H-1,3-benzoxazine (74405-16-6) → 2-hydroxy-pyridine N-oxide (13161-30-3) + salicylamide (65-45-2)

Guidance literature:

With hydrogenchloride; for 3h; Product distribution; Ambient temperature;

Reference yield: 85.0%

N-oxy-2-pyridyl phenacyl sulfoxide (65332-95-8) + 2,3-dimethyl-buta-1,3-diene (513-81-5) → 2-hydroxy-pyridine N-oxide (13161-30-3) + 2-Benzoyl-3,6-dihydro-4,5-dimethyl-2H-thiopyran (80738-10-9)

Guidance literature:

In 1,4-dioxane; at 100 ℃; for 24h; Yields of byproduct given;

DOI:10.1016/0040-4039(96)00673-9

upstream raw materials:

pyridine N-oxide

2-hydroxypyridin

2,2-dimethyl-4-(2-oxo-2H-pyrid-1-yl)oxy-2H-1,3-benzoxazine

N-oxy-2-pyridyl phenacyl sulfoxide

Downstream raw materials:

2-oxopyridin-1(2H)-yl benzenesulfonate

1-((4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzyl)oxy)pyridin-2(1H)-one

5-nitro-2-hydroxypyridine-N-oxide

2-oxopyridin-1(2H)-yl 2,4-dinitrobenzenesulfonate

Refernces

• 1、 Ribeiro da Silva, Maria D.M.C.,Matos, M. Agostinha R.,Miranda, Margarida S.,Morais, Victor M.F.,Acree Jr.. "Experimental and theoretical study of the dissociation enthalpy of the N-O bond on 2-hydroxypyridine N-oxide: Theoretical analysis of the energetics of the N-O bond for hydroxypyrydine N-oxide isomers". . p. 107 - 113. Retrieved 2004.
• 2、 Daniel, Kevin B.,Major Jourden, Jody L.,Negoescu, Kimberly E.,Cohen, Seth M.. "Activation of sulfonate ester based matrix metalloproteinase proinhibitors by hydrogen peroxide". body text. p. 313 - 323. Retrieved 2012/01/13.
• 3、 Jain, Suman L.,Sain, Bir. "Ruthenium catalyzed oxidation of tertiary nitrogen compounds with molecular oxygen: An easy access to N-oxides under mild conditions". . p. 1040 - 1041. Retrieved 2007/10/03.