MPEP hydrochloride

Base Information

• Chemical Name: MPEP hydrochloride
• CAS No.: 219911-35-0
• Molecular Formula: C14H11 N . Cl H
• Molecular Weight: 229.7
• Hs Code.: 2933399090
• UNII: AU9X845ZWM
• DSSTox Substance ID: DTXSID9043982
• Wikidata: Q27133082
• Metabolomics Workbench ID: 63193
• ChEMBL ID: CHEMBL1255868
• Mol file: 219911-35-0.mol

Synonyms:MPEP hydrochloride;219911-35-0;2-methyl-6-(phenylethynyl)pyridine hydrochloride;6-Methyl-2-(phenylethynyl)pyridine hydrochloride;MPEP HCl;MPEP (Hydrochloride);MPEP(HCl);UNII-AU9X845ZWM;AU9X845ZWM;CHEBI:64158;2-methyl-6-(2-phenylethynyl)pyridine;hydrochloride;2-methyl-6-(phenylethynyl)pyridinium chloride;6-methyl-2-(phenylethynyl)pyridinium chloride;SR-01000075996;MFCD02262119;EU-0100738;6-METHYL-2-(PHENYLETHYNYL)-PYRIDINE HCL;C14H11N.HCl;MLS002153163;SCHEMBL660360;2-METHYL-6-(PHENYLETHYNYL)PYRIDINE,HYDROCHLORIDE;CHEMBL1255868;DTXSID9043982;2-METHYL-6-(PHENYLETHYNYL)PYRIDINE, HYDROCHLORIDE;EX-A194;BCP09452;Tox21_500738;HB0426;AKOS024456469;CCG-222042;CS-0793;LP00738;2-methyl-6-(phenylethynyl)pyridine hcl;NCGC00094081-01;NCGC00261423-01;AC-32870;AC-35261;AS-55809;HY-14609;SMR001230657;FT-0762070;219911-35-0 (HCl);2-methyl-6-(phenylethynyl)pyridinehydrochloride;2-Methyl-6-phenylethynyl-pyridine hydrochloride;A13236;M 5435;N10886;6-Methyl-2-(phenylethynyl)pyridine, hydrochloride;SR-01000075996-1;SR-01000075996-3;Pyridine, 2-methyl-6-(phenylethynyl)-, hydrochloride;Pyridine, 6-methyl-2-(phenylethynyl)-, hydrochloride;Q27133082;2- methyl- 6- (2- phenylethynyl)- pyridine, monohydrochloride;6-Methyl-2-(phenylethynyl)pyridine hydrochloride, >=98% (HPLC);PYRIDINE, 2-METHYL-6-(2-PHENYLETHYNYL)-, HYDROCHLORIDE (1:1)

Chemical Property of MPEP hydrochloride

Chemical Property:

• Vapor Pressure: 0.000221mmHg at 25°C
• Melting Point: 145-146℃
• Boiling Point: 336.3°Cat760mmHg
• Flash Point: 144.8°C
• PSA: 12.89000
• Density: 1.1g/cm³
• LogP: 3.59180
• Storage Temp.: room temp
• Solubility.: DMSO: 10 mg/mL
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 2
• Exact Mass: 229.0658271
• Heavy Atom Count: 16
• Complexity: 251

Purity/Quality:

98%,99%, ^*data from raw suppliers

MPEPHydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Canonical SMILES: CC1=NC(=CC=C1)C#CC2=CC=CC=C2.Cl
• Description: Glutamate, the major excitatory neurotransmitter in the brain, acts on both ionotropic and metabotropic glutamate receptors. Excessive metabotropic glutamate receptor (mGluR) transmission has been linked to epilepsy, ischemia, pain, anxiety, and depression. Eight subtypes (1-8) and multiple splice variants of the mGluR have been identified and grouped based on their pharmacological properties. Group I mGluRs (subtypes 1 and 5) activate the phosphatidyl inositol pathway, while Group II (2 and 3) and Group III (4, 6, 7 and 8) inhibit adenylyl cyclase. MPEP is a potent, highly selective non-competitive antagonist at the mGlu5a receptor subtype (IC50 = 36 nM) while having no agonist or antagonist activities at the mGlu1b receptor at concentrations up to 30 μM. MPEP is centrally active following systemic administration in vivo, inducing anxiolytic-like effects in rodent models of anxiety and depression when administered at 1-30 mg/kg. MPEP has also been reported as a positive allosteric modulator of mGluR4 at μM concentrations.
• Uses: Glutamate, the major excitatory neurotransmitter in the brain, acts on both ionotropic and metabotropic glutamate receptors. Excessive metabotropic glutamate receptor (mGluR) transmission has been linked to epilepsy, ischemia, pain, anxiety, and depression. Eight subtypes (1-8) and multiple splice variants of the mGluR have been identified and grouped based on their pharmacological properties. Group I mGluRs (subtypes 1 and 5) activate the phosphatidyl inositol pathway, while Group II (2 and 3) and Group III (4, 6, 7 and 8) inhibit adenylyl cyclase. MPEP is a potent, highly selective non-competitive antagonist at the mGlu5a receptor subtype (IC50 = 36 nM) while having no agonist or antagonist activities at the mGlu1b receptor at concentrations up to 30 μM. MPEP is centrally active following systemic administration in vivo, inducing anxiolytic-like effects in rodent models of anxiety and depression when administered at 1-30 mg/kg. MPEP has also been reported as a positive allosteric modulator of mGluR4 at μM concentrations. MPEP is a potent and highly selective non-competitive mGlu5a receptor antagonist (1,2). It is also a positive allosteric modulator at mGlu4 receptors.MPEP exhibits anxiolytic and antidepressant properties that may be applicable for treating schizophrenia (3).