N,N-bis(2-chloroethyl)propan-1-amine

Base Information

• Chemical Name: N,N-bis(2-chloroethyl)propan-1-amine
• CAS No.: 621-68-1
• Molecular Formula: C7H15Cl2N
• Molecular Weight: 184.1067
• Mol file: 621-68-1.mol

Synonyms:Propylamine,N,N-bis(2-chloroethyl);bis-(2-chloro-ethyl)-propyl-amine;Bis-(2-chlor-aethyl)-propyl-amin;N,N-Bis(2-chloroethyl)propylamine;

Chemical Property of N,N-bis(2-chloroethyl)propan-1-amine

Chemical Property:

• Vapor Pressure: 2.49mmHg at 25°C
• Refractive Index: 1.5690 (estimate)
• Boiling Point: 159.6°Cat760mmHg
• Flash Point: 50.3°C
• PSA: 3.24000
• Density: 1.057g/cm³
• LogP: 2.17600

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of N,N-bis(2-chloroethyl)propan-1-amine

There total 1 articles about N,N-bis(2-chloroethyl)propan-1-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 49.0%

2,2'-(n-propylimino)bisethanol (6735-35-9) → bis(2-chloroethyl)propylamine (621-68-1)

Guidance literature:

2,2'-(n-propylimino)bisethanol; With thionyl chloride; for 2h; Reflux;

With sodium hydroxide; In water; pH=9;

DOI:10.1039/c7dt01032j

Reference yield:

bis(2-chloroethyl)propylamine (621-68-1) → 1-n-Propyl-4-<4-(4-brom-benzoyloxy)-phenyl>-piperazin (90863-17-5)

Guidance literature:

Multi-step reaction with 2 steps

1: H₂O; acetone / 0.5 h / Heating

2: 1.) Na / 1.) methanol; 2.) benzene

With sodium; In water; acetone;

Reference yield:

bis(2-chloroethyl)propylamine (621-68-1) → 4-Cyano-benzoic acid 4-(4-propyl-piperazin-1-yl)-phenyl ester (90863-20-0)

Guidance literature:

Multi-step reaction with 2 steps

1: H₂O; acetone / 0.5 h / Heating

2: 1.) Na / 1.) methanol; 2.) benzene

With sodium; In water; acetone;

upstream raw materials:

2,2'-(n-propylimino)bisethanol

Downstream raw materials:

1-(4-Heptyloxy-phenyl)-4-propyl-piperazine

4-(4-propyl-1-piperazinyl)phenol

4-Nitro-benzoic acid 4-(4-propyl-piperazin-1-yl)-phenyl ester

4-Fluoro-benzoic acid 4-(4-propyl-piperazin-1-yl)-phenyl ester

Refernces