Technology Process of 2-Hydroxy-2-methylbutyric acid
There total 34 articles about 2-Hydroxy-2-methylbutyric acid which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
methyl iodide;
With
magnesium;
In
tetrahydrofuran;
at 35 ℃;
for 0.5h;
Inert atmosphere;
2-Oxobutyric acid;
With
1,3-dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidinone;
In
tetrahydrofuran;
at 20 - 40 ℃;
for 2h;
Inert atmosphere;
- Guidance literature:
-
ethyl bromide;
With
magnesium;
In
tetrahydrofuran;
at 35 ℃;
for 0.5h;
Inert atmosphere;
2-oxo-propionic acid;
With
N,N,N,N,N,N-hexamethylphosphoric triamide;
In
tetrahydrofuran;
at 20 - 40 ℃;
for 2h;
Inert atmosphere;
- Guidance literature:
-
With
potassium hydroxide;
for 1h;
Ambient temperature;
DOI:10.1248/cpb.47.684