N-(4,5-DIMETHYL-2-NITRO-PHENYL)-ACETAMIDE

Base Information

• Chemical Name: N-(4,5-DIMETHYL-2-NITRO-PHENYL)-ACETAMIDE
• CAS No.: 6970-77-0
• Molecular Formula: C10H12N2O3
• Molecular Weight: 208.217
• Hs Code.: 2924299090
• Mol file: 6970-77-0.mol

Synonyms:3',4'-Acetoxylidide,6'-nitro- (6CI,7CI);N-(4,5-Dimethyl-2-nitrophenyl)acetamide;NSC 62092;

Chemical Property of N-(4,5-DIMETHYL-2-NITRO-PHENYL)-ACETAMIDE

Chemical Property:

• Vapor Pressure: 7.52E-07mmHg at 25°C
• Melting Point: 108 °C(Solv: ethanol (64-17-5))
• Refractive Index: 1.595
• Boiling Point: 407.5 °C at 760 mmHg
• PKA: 13.84±0.70(Predicted)
• Flash Point: 200.2 °C
• PSA: 74.92000
• Density: 1.247g/cm³
• LogP: 2.76620

Purity/Quality:

N-(4,5-Dimethyl-2-nitro-phenyl)acetamide ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of N-(4,5-DIMETHYL-2-NITRO-PHENYL)-ACETAMIDE

There total 8 articles about N-(4,5-DIMETHYL-2-NITRO-PHENYL)-ACETAMIDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

4,5-dimethyl-2-nitrobenzenamine (6972-71-0) + acetic anhydride (108-24-7) → N-(4,5-dimethyl-2-nitrophenyl)acetamide (6970-77-0)

Guidance literature:

With acetic acid; for 1h; Heating;

DOI:10.1021/ac9801723

Reference yield: 97.0%

4,5-dimethyl-2-nitrobenzenamine (6972-71-0) + acetic anhydride (108-24-7) + acetic acid (64-19-7,77671-22-8) → N-(4,5-dimethyl-2-nitrophenyl)acetamide (6970-77-0)

Guidance literature:

at 90 ℃; for 2h; Reflux;

Reference yield:

4-amino-o-xylene (95-64-7) → N-(4,5-dimethyl-2-nitrophenyl)acetamide (6970-77-0)

Guidance literature:

Multi-step reaction with 2 steps

1: acetic acid; H₂O / 1 h / 60 °C

2: 70 percent aq. HNO₃, AcOH / 1 h / below 15 deg C

With nitric acid; acetic acid; In water; acetic acid;

DOI:10.1055/s-1995-4088

upstream raw materials:

4,5-dimethyl-2-nitrobenzenamine

acetic anhydride

4-amino-o-xylene

nitric acid

Downstream raw materials:

4,5-dimethyl-2-nitrobenzenamine

acetic acid-(2-amino-4,5-dimethyl-anilide)

5,6-dimethyl-8-nitroquinoline

4-amino-5-nitrophthalic acid

Refernces

• 1、 -. "MACROCYCLIC COMPOUNDS". Paragraph 00376; 00377; 00378; 00379. . Retrieved 2018/10/19.
• 2、 Kojima, Hirotatsu,Nakatsubo, Naoki,Kikuchi, Kazuya,Kawahara, Shigenori,Kirino, Yutaka,Nagoshi, Hiroshi,Hirata, Yasunobu,Nagano, Tetsuo. "Detection and Imaging of Nitric Oxide with Novel Fluorescent Indicators: Diaminofluoresceins". . p. 2446 - 2453. Retrieved 2007/10/03.