L-Valine hydrochloride

Base Information

• Chemical Name: L-Valine hydrochloride
• CAS No.: 17498-50-9
• Molecular Formula: C₅H₁₁NO₂*ClH
• Molecular Weight: 153.609
• Hs Code.: 2922499990
• European Community (EC) Number: 241-505-8
• DSSTox Substance ID: DTXSID30938605
• Mol file: 17498-50-9.mol

Synonyms:L-Valine hydrochloride;17498-50-9;(S)-2-Amino-3-methylbutanoic acid hydrochloride;L-Valine (hydrochloride);L-Valine, hydrochloride (1:1);(2S)-2-amino-3-methylbutanoic acid;hydrochloride;[(1S)-1-carboxy-2-methylpropyl]azanium;chloride;L-Valine HCl;EINECS 241-505-8;(2S)-2-amino-3-methylbutanoic acid hydrochloride;L-(+)-valine hydrochloride;SCHEMBL132740;DTXSID30938605;JETBVOLWZWPMKR-WCCKRBBISA-N;Valine--hydrogen chloride (1/1);AKOS015892991;HY-W142137;CS-0201920;NS00084971;(S)-2-Amino-3-methylbutanoicacidhydrochloride;A881645

Chemical Property of L-Valine hydrochloride

Chemical Property:

• Vapor Pressure: 0.0633mmHg at 25°C
• Boiling Point: 213.6 °C at 760 mmHg
• Flash Point: 83 °C
• PSA: 63.32000
• LogP: 1.55660
• Storage Temp.: 2-8°C
• Hydrogen Bond Donor Count: 3
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 2
• Exact Mass: 153.0556563
• Heavy Atom Count: 9
• Complexity: 90.4

Purity/Quality:

99%, ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC(C)C(C(=O)O)N.Cl
• Isomeric SMILES: CC(C)[C@@H](C(=O)O)N.Cl

Technology Process of L-Valine hydrochloride

There total 65 articles about L-Valine hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

C20H34N4O4 (213686-07-8) → (2R,5S)-2,5-diaminohexan-1,6-dioic acid (40872-10-4) + L-valine hydrochloride (17498-50-9,25616-14-2,31320-20-4)

Guidance literature:

With hydrogenchloride; for 2h; Heating;

DOI:10.1016/S0040-4020(98)00492-X

Reference yield: 80.0%

C20H34N4O4 (213686-06-7) → L-valine hydrochloride (17498-50-9,25616-14-2,31320-20-4) + (2R,5R)-2,5-diaminohexan-1,6-dioic acid

Guidance literature:

With hydrogenchloride; for 2h; Heating;

DOI:10.1016/S0040-4020(98)00492-X

Reference yield: 77.0%

isopropyl 4-iodo-3-methyl-2-(trifluoroacetamido)butanoate (652157-21-6) → L-valine hydrochloride (17498-50-9,25616-14-2,31320-20-4)

Guidance literature:

With hydrogen; palladium on activated charcoal; In methanol; for 4h;

DOI:10.1002/ejoc.200300410

upstream raw materials:

t-Boc-L-valine

L-valine ethyl ester

(S)-2-(benzylamino)-3-methylbutanoic acid

<(1S,2R)-10-(N,N-dicyclohexylaminosulfonyl)born-2-yl> (2R)-2-aminoisovalerate

Downstream raw materials:

N-trifluoroacetyl-L-valine

N-phthaloyl L-valine

(2R)-2-(benzoylamino)-3-methylbutyric acid

(R)-2-[(E)-3-(2,4-Dimethoxy-phenyl)-acryloylamino]-3-methyl-butyric acid ethyl ester

Refernces

• 1、 Chapkanov,Zareva. "L-valine and L-proline - solid-state IR-LD spectroscopic study". . p. 347 - 350. Retrieved 2010.
• 2、 Mollica, Adriano,Costante, Roberto,Mirzaie, Sako,Carradori, Simone,Macedonio, Giorgia,Stefanucci, Azzurra,Novellino, Ettore. "Preparation of Constrained Unnatural Aromatic Amino Acids via Unsaturated Diketopiperazine Intermediate". . p. 2106 - 2110. Retrieved 2016/11/23.
• 3、 Kishimoto, Shinji,Tsunematsu, Yuta,Nishimura, Shinichi,Hayashi, Yutaka,Hattori, Akira,Kakeya, Hideaki. "Tumescenamide C, an antimicrobial cyclic lipodepsipeptide from Streptomyces sp.". experimental part. p. 5572 - 5578. Retrieved 2012/09/08.