1,2,3-trichloro-4-iodobenzene

Base Information

• Chemical Name: 1,2,3-trichloro-4-iodobenzene
• CAS No.: 62720-28-9
• Molecular Formula: C6H2Cl3I
• Molecular Weight: 307.345
• Hs Code.: 2903999090
• Mol file: 62720-28-9.mol

Synonyms:trichloroiodobenzene;1,2,3-trichloro-4-iodo-benzene;2,3,4-trichloroiodobenzene;

Chemical Property of 1,2,3-trichloro-4-iodobenzene

Chemical Property:

• Vapor Pressure: 0.00234mmHg at 25°C
• Boiling Point: 297.8°Cat760mmHg
• Flash Point: 133.9°C
• PSA: 0.00000
• Density: 2.085g/cm³
• LogP: 4.25140

Purity/Quality:

1-IODO-2,3,4-TRICHLOROBENZENE Aldrich ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 1,2,3-Trichloro-4-iodobenzene is an intermediate in the synthesis of 2,2'',3,3'',4,4''-Hexachlorobiphenyl (H290825), a polychlorinated biphenyl (PCB) found in air, soil, mammals, and marine animals.

Technology Process of 1,2,3-trichloro-4-iodobenzene

There total 1 articles about 1,2,3-trichloro-4-iodobenzene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2,3,4-trichloroaniline (634-67-3) → 1,2,3-trichloro-4-iodobenzene (62720-28-9)

Guidance literature:

With sulfuric acid; acetic acid; potassium iodide; sodium nitrite; Yield given. Multistep reaction; 1.)0-5 deg C; 2.)heated;

Reference yield: 83.0%

C13H20N2O4 (845907-12-2) + 1,2,3-trichloro-4-iodobenzene (62720-28-9) → 2-({1-[3-(2,3,4-trichloro-phenyl)-acryloyl]-piperidine-4-carbonyl}-amino)-propionic acid methyl ester

Guidance literature:

With triethylamine; palladium diacetate; tris-(o-tolyl)phosphine; In DMF (N,N-dimethyl-formamide); at 85 ℃; for 8h;

Reference yield: 43.0%

1,2,3-trichloro-4-iodobenzene (62720-28-9) + 8-mercaptoadenine (7390-62-7) → 8-((2,3,4-trichlorophenyl)thio)-9H-purin-6-amine

Guidance literature:

With copper(l) iodide; 2,9-dimethyl-1,10-phenanthroline hydrate; sodium t-butanolate; In N,N-dimethyl-formamide; at 110 ℃; for 24h; Inert atmosphere;

DOI:10.1021/acs.jmedchem.5b00197

upstream raw materials:

2,3,4-trichloroaniline

Downstream raw materials:

1,2,3-trichlorobenzene

2,2',3,4,6'-pentachlorobiphenyl

2,3,3',4-tetrachlorobiphenyl

4,4'-Dimethoxybiphenyl

Refernces

• 1、 Bolton, Roger,Moore, Clive,Sandall, John P.B.. "Nucleophilic Displacement in Polyhalogenoaromatic Compounds. Part 11. Kinetics of Protiodeiodination of Iodoarenes in Dimethyl Sulphoxide-Methanol". . p. 1593 - 1598. Retrieved 2007/10/02.