2-(2,4-DIHYDROXYBENZOYL)BENZOIC ACID

Base Information

• Chemical Name: 2-(2,4-DIHYDROXYBENZOYL)BENZOIC ACID
• CAS No.: 2513-33-9
• Molecular Formula: C14H10 O5
• Molecular Weight: 258.23
• Hs Code.: 2918992090
• Mol file: 2513-33-9.mol

Synonyms:Benzoicacid, o-b-resorcyloyl- (6CI,7CI,8CI);2-(2,4-Dihydroxybenzoyl)benzoic acid; 2-(2',4'-Dihydroxybenzoyl)benzoic acid;2-Carboxy-2',4'-dihydroxybenzophenone; 2',4'-Dihydroxy-2-benzoylbenzoic acid;NSC 14699; NSC 50144

Chemical Property of 2-(2,4-DIHYDROXYBENZOYL)BENZOIC ACID

Chemical Property:

• Vapor Pressure: 3.47E-13mmHg at 25°C
• Melting Point: 202-205°C (dec.)
• Boiling Point: 555.7°Cat760mmHg
• PKA: 3.26±0.36(Predicted)
• Flash Point: 304°C
• PSA: 94.83000
• Density: 1.459g/cm³
• LogP: 2.02700
• Storage Temp.: Refrigerator, Under Inert Atmosphere

Purity/Quality:

99%, ^*data from raw suppliers

2'',4''-Dihydroxy-2-benzoylbenzoicAcid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: A by-product of Fluorescein.

Technology Process of 2-(2,4-DIHYDROXYBENZOYL)BENZOIC ACID

There total 20 articles about 2-(2,4-DIHYDROXYBENZOYL)BENZOIC ACID which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

fluorescein (2321-07-5,126605-73-0) → 2-(2,4-dihydroxybenzoyl)benzoic acid (2513-33-9)

Guidance literature:

With sodium hydroxide; In water; for 1h; Reflux; Inert atmosphere;

Reference yield: 90.0%

C18H18O7 (1384988-00-4) → 2-(2,4-dihydroxybenzoyl)benzoic acid (2513-33-9)

Guidance literature:

With hydrogenchloride; In 1,4-dioxane; at 20 ℃; for 3h;

DOI:10.1021/jo300177b

Reference yield: 89.0%

phthalic anhydride (85-44-9) + recorcinol (108-46-3) → 2-(2,4-dihydroxybenzoyl)benzoic acid (2513-33-9)

Guidance literature:

With aluminium trichloride; In nitrobenzene; Ambient temperature;

upstream raw materials:

phthalic anhydride

recorcinol

spiro[isobenzofuran-3',6'-dihydroxy-1(3H),9'-[9H]thioxanthen]-3-one

fluorescein

Downstream raw materials:

2-(2,4-dihydroxy-benzyl)-benzoic acid

3,5-dibromo-2'-carboxy-2,4-dihydroxybenzophenone

fluorescein

3-(2,4-dihydroxy-phenyl)-3-(4-hydroxy-phenyl)-phthalide

Refernces

• 1、 Huang, Kunzhu,Yu, Lun,Xu, Pengfei,Zhang, Xintong,Zeng, Wenbin. "A novel FRET-based ratiometric fluorescent probe for highly sensitive detection of hydrogen sulfide". . p. 17797 - 17801. Retrieved 2015.
• 2、 Cheng, Zhi-Qiang,Ge, Yong-Xi,Jiang, Cheng-Shi,Li, Ning,Wang, Kai-Ming,Xie, Hong-Xu,Zhang, Juan,Zhou, Aiqin,Zhou, Lei,Zhu, Kongkai. "A highly sensitive endoplasmic reticulum-targeting fluorescent probe for the imaging of endogenous H2S in live cells". . . Retrieved 2020.
• 3、 Zhao, Qi,Huo, Fangjun,Kang, Jin,Zhang, Yongbin,Yin, Caixia. "A novel FRET-based fluorescent probe for the selective detection of hydrogen sulfide (H2S) and its application for bioimaging". . p. 4903 - 4908. Retrieved 2018.