2-Hydroxy-3-morpholinopropanesulfonic Acid

Base Information

• Chemical Name: 2-Hydroxy-3-morpholinopropanesulfonic Acid
• CAS No.: 68399-77-9
• Deprecated CAS: 165552-32-9
• Molecular Formula: C7H15NO5S
• Molecular Weight: 225.266
• Hs Code.: 29349990
• European Community (EC) Number: 269-989-6
• UNII: 6XB7PS9THL
• DSSTox Substance ID: DTXSID40887352
• Nikkaji Number: J208.608E
• Wikipedia: 2-Hydroxy-3-morpholinopropanesulfonic_acid
• Mol file: 68399-77-9.mol

Synonyms:3-morpholino-2-hydroxypropanesulfonic acid;3-morpholino-2HOPSA

Chemical Property of 2-Hydroxy-3-morpholinopropanesulfonic Acid

Chemical Property:

• Appearance/Colour: white crystalline powder
• Melting Point: 275-280 °C (dec.)
• Refractive Index: 1.539
• PKA: pK1:6.75 (37°C)
• PSA: 95.45000
• Density: 1.416 g/cm³
• LogP: -0.41400
• Storage Temp.: Store at RT.
• Solubility.: H2O: 0.5 M at 20 °C, clear
• Water Solubility.: Water solubility under desired conditions ca.112,6 g/L at 20°C.
• XLogP3: -4.1
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 6
• Rotatable Bond Count: 4
• Exact Mass: 225.06709375
• Heavy Atom Count: 14
• Complexity: 254

Purity/Quality:

99%, ^*data from raw suppliers

MOPSO Free Acid ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36-37/39

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Chemical Classes: Nitrogen Compounds -> Morpholines
• Canonical SMILES: C1COCCN1CC(CS(=O)(=O)O)O
• Uses: MOPSO is a buffer that works in the 6-7 pH range. Used in pharmaceutical synthesis. MOPSO is a biological buffer also referred to as a second generation “Good′s” buffer which displays improved solubility compared to traditional “Good′s” buffers. The pKa of MOPSO is 6.9 which make it an ideal candidate for buffer formulations which require a pH slightly below physiological to maintain a stable environment in solution. MOPSO is considered to be non-toxic to culture cell lines and provides high-solution clarity.MOPSO can be used in cell culture media, biopharmaceutical buffer formulations (both upstream and downstream) and diagnostic reagents.

Technology Process of 2-Hydroxy-3-morpholinopropanesulfonic Acid

There total 3 articles about 2-Hydroxy-3-morpholinopropanesulfonic Acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

morpholine (110-91-8,99108-56-2) + sodium 3-chloro-2-hydroxypropane-sulfonate (126-83-0) → 3-(N-Morpholino)-2-hydroxypropanesulfonic acid (68399-77-9)

Guidance literature:

In water;

Reference yield:

morpholine (110-91-8,99108-56-2) + sodium 2-hydroxypropane-1-sulfonate (1561-96-2) → 3-(N-Morpholino)-2-hydroxypropanesulfonic acid (68399-77-9)

Guidance literature:

for 3.5h; Reflux;

Reference yield:

→ 3-(N-Morpholino)-2-hydroxypropanesulfonic acid (68399-77-9)

Guidance literature:

upstream raw materials:

morpholine

sodium 3-chloro-2-hydroxypropane-sulfonate

sodium 2-hydroxypropane-1-sulfonate

Refernces

• 1、 -. "ENHANCING AGENT FOR DETECTION OF ANALYTE IN SPECIMEN, AND METHOD FOR DETECTING ANALYTE IN SPECIMEN". . . Retrieved 2020/11/30.
• 2、 -. "Stabilizing labeled antibody using amino acids". . . Retrieved 2011/11/07.