diphenyl(thiophen-2-yl)acetic acid

Base Information

• Chemical Name: diphenyl(thiophen-2-yl)acetic acid
• CAS No.: 5449-99-0
• Molecular Formula: C18H14 O2 S
• Molecular Weight: 294.3676
• Mol file: 5449-99-0.mol

Synonyms:NSC16466

Chemical Property of diphenyl(thiophen-2-yl)acetic acid

Chemical Property:

• Vapor Pressure: 2.38E-07mmHg at 25°C
• Boiling Point: 406.9°Cat760mmHg
• Flash Point: 199.9°C
• Density: 1.261g/cm³

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of diphenyl(thiophen-2-yl)acetic acid

There total 1 articles about diphenyl(thiophen-2-yl)acetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

thiophene (188290-36-0,8014-23-1,25233-34-5) + Benzilic acid (76-93-7) → diphenyl-2-thiophenyl acetic acid (5449-99-0)

Guidance literature:

With sulfuric acid; acetic acid;

DOI:10.1002/hlca.19310140112

Reference yield: 89.0%

diphenyl-2-thiophenyl acetic acid (5449-99-0) + phenethylamine (64-04-0) → C26H23NOS (1094038-98-8)

Guidance literature:

With benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In dichloromethane; at 25 ℃; for 12h; Inert atmosphere;

DOI:10.1016/j.bmcl.2008.07.128

Reference yield: 74.0%

diphenyl-2-thiophenyl acetic acid (5449-99-0) + D-phenylalanine methyl ester hydrochloride (13033-84-6) → C28H25NO3S (1094039-15-2)

Guidance literature:

With benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In dichloromethane; at 25 ℃; for 12h; Inert atmosphere;

DOI:10.1016/j.bmcl.2008.07.128

upstream raw materials:

thiophene

Benzilic acid

Downstream raw materials:

(2-thienyl)diphenylmethane

diphenyl(2-thienyl)methanol

C₂₈H₂₅NO₃S

C₂₆H₂₃NOS