3-PHENETHYL-PHENOL

Base Information

• Chemical Name: 3-PHENETHYL-PHENOL
• CAS No.: 33675-75-1
• Molecular Formula: C14H14O
• Molecular Weight: 198.26
• Hs Code.: 2907199090
• Mol file: 33675-75-1.mol

Synonyms:Phenol,m-phenethyl- (8CI);1-m-Hydroxyphenyl-2-phenylethane;3-Phenethylphenol;3-(2-Phenylethyl)phenol;1-(3-Hydroxyphenyl)-2-phenylethane;

Chemical Property of 3-PHENETHYL-PHENOL

Chemical Property:

• Vapor Pressure: 0.000178mmHg at 25°C
• Refractive Index: 1.601
• Boiling Point: 319.7 °C at 760 mmHg
• Flash Point: 151.6 °C
• PSA: 20.23000
• Density: 1.093 g/cm³
• LogP: 3.17740
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

98%min ^*data from raw suppliers

3-Phenethylphenol ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-PHENETHYL-PHENOL

There total 20 articles about 3-PHENETHYL-PHENOL which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

1-(methoxymethoxy)-3-phenethylbenzene → 3-hydroxybibenzyl (33675-75-1)

Guidance literature:

With hydrogenchloride; In methanol; water; Reflux;

DOI:10.1021/jo3000805

Reference yield: 63.0%

3-(2-cyanophenethyl)phenyl pivalate → 3-hydroxybibenzyl (33675-75-1) + 2-(3-hydroxyphenethyl)benzonitrile

Guidance literature:

With titanium(IV) isopropylate; bis(1,5-cyclooctadiene)nickel ⁽⁰⁾; sodium t-butanolate; tricyclohexylphosphine; In toluene; at 120 ℃; for 16h; Inert atmosphere;

DOI:10.1021/acs.orglett.0c03138

Reference yield:

(E)-3-hydroxystilbene (17861-18-6) → 3-hydroxybibenzyl (33675-75-1)

Guidance literature:

With hydrogen; palladium on activated charcoal; In ethanol; for 20h;

DOI:10.1021/jm00168a043

upstream raw materials:

(E)-3-hydroxystilbene

benzyl chloride

3-methyl-phenol

benzylchlorotriphenylphosphorane

Downstream raw materials:

3-(4-dimethylaminobutoxy)bibenzyl

Refernces

• 1、 Adams, David R.,Tawati, Salha,Berretta, Giacomo,Rivas, Paula Lopez,Baiget, Jessica,Jiang, Zhong,Alsfouk, Aisha,Mackay, Simon P.,Pyne, Nigel J.,Pyne, Susan. "Topographical Mapping of Isoform-Selectivity Determinants for J-Channel-Binding Inhibitors of Sphingosine Kinases 1 and 2". . p. 3658 - 3676. Retrieved 2019/04/26.
• 2、 Wilhelm, Anke,Kendrekar, Pravin,Noreljaleel, Anwar E. M.,Abay, Efrem T.,Bonnet, Susan L.,Wiesner, Lubbe,De Kock, Carmen,Swart, Kenneth J.,Van Der Westhuizen, Jan Hendrik. "Syntheses and in Vitro Antiplasmodial Activity of Aminoalkylated Chalcones and Analogues". . p. 1848 - 1858. Retrieved 2015/09/08.