6-CHLORO-2-(4-CHLOROPHENYL)-4-QUINOLINE CARBOXYLIC ACID

Base Information

• Chemical Name: 6-CHLORO-2-(4-CHLOROPHENYL)-4-QUINOLINE CARBOXYLIC ACID
• CAS No.: 126088-20-8
• Molecular Formula: C16H9Cl2NO2
• Molecular Weight: 318.159
• Hs Code.: 2933499090
• Mol file: 126088-20-8.mol

Synonyms:6-Chloro-2-(4-chlorophenyl)quinoline-4-carboxylicacid;4-quinolinecarboxylic acid, 6-chloro-2-(4-chlorophenyl)-;

Chemical Property of 6-CHLORO-2-(4-CHLOROPHENYL)-4-QUINOLINE CARBOXYLIC ACID

Chemical Property:

• Vapor Pressure: 4.25E-11mmHg at 25°C
• Melting Point: 288
• Boiling Point: 506.9 °C at 760 mmHg
• PKA: 0.66±0.30(Predicted)
• Flash Point: 260.4 °C
• PSA: 50.19000
• Density: 1.456 g/cm³
• LogP: 4.90680

Purity/Quality:

98%min ^*data from raw suppliers

6-Chloro-2-(4-chlorophenyl)quinoline-4-carboxylicAcid ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 6-CHLORO-2-(4-CHLOROPHENYL)-4-QUINOLINE CARBOXYLIC ACID

There total 2 articles about 6-CHLORO-2-(4-CHLOROPHENYL)-4-QUINOLINE CARBOXYLIC ACID which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 50.0%

4-chlorobenzaldehyde (104-88-1) + 4-chloro-aniline (106-47-8) + 2-oxo-propionic acid (127-17-3) → 6-chloro-2-(4-chlorophenyl)quinoline-4-carboxylic acid (126088-20-8)

Guidance literature:

With toluene-4-sulfonic acid; In ethanol; for 0.05h; Microwave irradiation; Green chemistry;

DOI:10.1002/jhet.3848

Reference yield: 42.0%

5-chloroindole 2,3-dione (17630-76-1) + para-chloroacetophenone (99-91-2) → 6-chloro-2-(4-chlorophenyl)quinoline-4-carboxylic acid (126088-20-8)

Guidance literature:

With sodium hydroxide; In ethanol; water; for 48 - 72h; Heating;

Reference yield: 72.0%

6-chloro-2-(4-chlorophenyl)quinoline-4-carboxylic acid (126088-20-8) + benzyl-methyl-amine (103-67-3) → N-benzyl-6-chloro-2-(4-chlorophenyl)-N-methylquinoline-4-carboxamide

Guidance literature:

With dmap; dicyclohexyl-carbodiimide; In dichloromethane; at 20 ℃;

DOI:10.1016/j.bioorg.2021.105486

upstream raw materials:

5-chloroindole 2,3-dione

para-chloroacetophenone

4-chlorobenzaldehyde

4-chloro-aniline

Downstream raw materials:

C₁₆H₈NOCl₂Cl

6-chloro-2-(4-chlorophenyl)quinoline-4-carboxylic acid hydrazide

Refernces

• 1、 Patel, Dhaval B.,Patel, Hitesh D.,Rajani, Dhanji P.,Rajani, Smita D.. "A green synthesis of quinoline-4-carboxylic derivatives using p-toluenesulfonic acid as an efficient organocatalyst under microwave irradiation and their docking, molecular dynamics, ADME-Tox and biological evaluation". . . Retrieved 2020/02/27.