4-Pyridinecarboxylicacid, 2-phenylhydrazide

Base Information

• Chemical Name: 4-Pyridinecarboxylicacid, 2-phenylhydrazide
• CAS No.: 91396-88-2
• Molecular Formula: C₁₂H₁₁N₃O
• Molecular Weight: 213.239
• Mol file: 91396-88-2.mol

Synonyms:Isonicotinic acid, 2-phenylhydrazide (7CI);NSC 14613;Isonicotinic acid N'-phenyl-hydrazide;

Chemical Property of 4-Pyridinecarboxylicacid, 2-phenylhydrazide

Chemical Property:

• Melting Point: 177-178℃
• Boiling Point: 335.747 °C at 760 mmHg
• PKA: 10.69±0.23(Predicted)
• Flash Point: 156.855 °C
• PSA: 54.02000
• Density: 1.252 g/cm³
• LogP: 2.30240
• Storage Temp.: ?20°C
• Solubility.: DMSO: soluble15mg/mL, clear

Purity/Quality:

98%,99%, ^*data from raw suppliers

PluriSln 1 ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xn
• Hazard Codes: Xn
• Statements: 22-36
• Safety Statements: 26

MSDS Files:

SDS file from LookChem

Useful:

• Description: PluriSln-1 (91396-88-2) is an inhibitor of stearoyl-coA desaturase (SCD1). PluriSln-1 was able to selectively eliminate human pluripotent stem cells (hPSCs) while not affecting a large array of progenitor and differentiated cells.1?The ability to eliminate potentially tumorigenic undifferentiated cells is important for increasing the safety of hPSC-based treatments. PluriSln-1 has been used to successfully eliminate tumorigenic cells in cardiomyocytes2?and chondrogenic cells3.
• Uses: NSC 14613 is an inhibitor of the stearoyl-coA desaturase 1 (SCD1), which is able to selectively eliminate hPSCs.

Technology Process of 4-Pyridinecarboxylicacid, 2-phenylhydrazide

There total 1 articles about 4-Pyridinecarboxylicacid, 2-phenylhydrazide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-(chlorocarbonyl)pyridine (14254-57-0) + phenylhydrazine (100-63-0) → 4-pyridinecarboxylic acid 2-phenylhydrazide (91396-88-2)

Guidance literature:

With benzene;

DOI:10.1021/ja01104a046

Reference yield:

4-pyridinecarboxylic acid 2-phenylhydrazide (91396-88-2) → N-phenylpyridine-4-carbohydrazonoyl chloride (1353634-71-5)

Guidance literature:

With tetrachloromethane; triphenylphosphine; In acetonitrile; at 20 ℃; for 8h;

DOI:10.1039/d0cc01065k

Reference yield:

phosgene (75-44-5) + 4-pyridinecarboxylic acid 2-phenylhydrazide (91396-88-2) → 3-phenyl-5-[4]pyridyl-3H-[1,3,4]oxadiazol-2-one (101676-54-4)

Guidance literature:

With hydrogenchloride;

upstream raw materials:

4-(chlorocarbonyl)pyridine

phenylhydrazine

Downstream raw materials:

3-phenyl-5-[4]pyridyl-3H-[1,3,4]oxadiazol-2-one

N-phenylpyridine-4-carbohydrazonoyl chloride