[(2-methoxyphenyl)amino](phenyl)acetonitrile

Base Information

• Chemical Name: [(2-methoxyphenyl)amino](phenyl)acetonitrile
• CAS No.: 60561-59-3
• Molecular Formula: C15H14 N2 O
• Molecular Weight: 238.2845
• Mol file: 60561-59-3.mol

Synonyms:NSC406223

Chemical Property of [(2-methoxyphenyl)amino](phenyl)acetonitrile

Chemical Property:

• Vapor Pressure: 3.78E-06mmHg at 25°C
• Boiling Point: 385.5°Cat760mmHg
• Flash Point: 187°C
• Density: 1.166g/cm³

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of [(2-methoxyphenyl)amino](phenyl)acetonitrile

There total 3 articles about [(2-methoxyphenyl)amino](phenyl)acetonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

trimethylsilyl cyanide (7677-24-9) + 2-methoxy-phenylamine (90-04-0) + benzaldehyde (100-52-7) → α-[(2-methoxyphenyl)amino]-benzeneacetonitrile (60561-59-3)

Guidance literature:

With azaphosphatrane salt on Merrifield resin; In acetonitrile; at 20 ℃; for 15h;

DOI:10.1016/j.tet.2005.09.117

Reference yield: 98.0%

diethylaluminium cyanide (5804-85-3) + (E)-N-benzylidene-2-methoxybenzenamine (5877-56-5) → α-[(2-methoxyphenyl)amino]-benzeneacetonitrile (60561-59-3)

Guidance literature:

With (R)-1,1'-Bi-2-naphthol; In toluene; at -78 - -40 ℃; for 3h;

DOI:10.1016/j.tetasy.2004.03.040

Reference yield: 85.0%

→ α-[(2-methoxyphenyl)amino]-benzeneacetonitrile (60561-59-3)

Guidance literature:

With tert.-butylhydroperoxide; hemin; In methanol; at 25 ℃; for 2h;

upstream raw materials:

diethylaluminium cyanide

(E)-N-benzylidene-2-methoxybenzenamine

trimethylsilyl cyanide

2-methoxy-phenylamine

Refernces

• 1、 Singh, Harminder,Rajput, Jaspreet Kaur,Arora, Priya,Jigyasa. "Role of (3-aminopropyl)tri alkoxysilanes in grafting of chlorosulphonic acid immobilized magnetic nanoparticles and their application as heterogeneous catalysts for the green synthesis of α-aminonitriles". . p. 84658 - 84671. Retrieved 2016/10/31.
• 2、 Nakamura, Shuichi,Sato, Naoki,Sugimoto, Masashige,Toru, Takeshi. "A new approach to enantioselective cyanation of imines with Et 2AlCN". . p. 1513 - 1516. Retrieved 2007/10/03.