4-Desamino-4-hydroxy trimethoprim

Base Information Edit

Chemical Name:4-Desamino-4-hydroxy trimethoprim
CAS No.:92440-76-1
Molecular Formula:C14H17 N3 O4
Molecular Weight:291.307
Hs Code.:2933599090
European Community (EC) Number:296-233-2
UNII:2W6TXK5JQS
DSSTox Substance ID:DTXSID10239006
Nikkaji Number:J331.232A
Wikidata:Q27255688
Mol file:92440-76-1.mol

Synonyms:92440-76-1;4-Desamino-4-hydroxy trimethoprim;2-Amino-5-[(3,4,5-trimethoxyphenyl)methyl]-4(1H)-pyrimidinone;EINECS 296-233-2;2-amino-5-[(3,4,5-trimethoxyphenyl)methyl]-1H-pyrimidin-6-one;UNII-2W6TXK5JQS;2W6TXK5JQS;2-Amino-5-(3,4,5-trimethoxybenzyl)pyrimidin-4-ol;2-amino-5-[(3,4,5-trimethoxyphenyl)methyl]pyrimidin-4-ol;Trimethoprim EP Impurity D;2-Amino-5-(3,4,5-trimethoxybenzyl)-4-pyrimidinol;SCHEMBL7714729;DTXSID10239006;FT-0662094;TRIMETHOPRIM IMPURITY D [EP IMPURITY];5-(3,4,5-Trimethoxybenzyl)-2-aminopyrimidin-4-ol;2-Amino-5-(3,4,5-trimethoxybenzyl)-4-pyrimidinol #;Q27255688;2-Amino-4-chloro-5-[3,4,5-trimethoxybenzyl]pyrimidine;2-Amino-4-hydroxy-5-[3,4,5-trimethoxybenzyl]pyrimidine;4-PYRIMIDINOL, 2-AMINO-5-(3,4,5-TRIMETHOXYBENZYL)-;4(1H)-Pyrimidinone, 2-amino-5-[(3,4,5-trimethoxyphenyl)methyl]-;2-amino-5-[(3,4,5-trimethoxyphenyl)methyl]-3,4-dihydropyrimidin-4-one;4(3H)-PYRIMIDINONE, 2-AMINO-5-((3,4,5-TRIMETHOXYPHENYL)METHYL)-

Suppliers and Price of 4-Desamino-4-hydroxy trimethoprim

Supply Marketing:Edit

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
2-Amino-5-[(3,4,5-trimethoxyphenyl)methyl]-4(1H)-pyrimidinone
100mg
$ 545.00

Biosynth Carbosynth
2-Amino-5-[(3,4,5-trimethoxyphenyl)methyl]-4(1H)-pyrimidinone
100 mg
$ 255.00

American Custom Chemicals Corporation
TRIMETHOPRIM EP IMPURITY D 95.00%
5MG
$ 458.97

AK Scientific
4-Desamino-4-hydroxytrimethoprim
10mg
$ 252.00

Total 10 raw suppliers

Chemical Property of 4-Desamino-4-hydroxy trimethoprim Edit

Chemical Property:

Melting Point:257-258 °C(Solv: ethanol, 50% (64-17-5))
Boiling Point:°Cat760mmHg
PKA:9.40±0.50(Predicted)
Flash Point:°C
PSA：100.45000
Density:1.31g/cm³
LogP:1.31110
Storage Temp.:Hygroscopic, -20°C Freezer, Under inert atmosphere
Solubility.:DMSO (Slightly), Methanol (Slightly)
XLogP3:0.5
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:5
Exact Mass:291.12190603
Heavy Atom Count:21
Complexity:436

Purity/Quality:

99% ^*data from raw suppliers

2-Amino-5-[(3,4,5-trimethoxyphenyl)methyl]-4(1H)-pyrimidinone ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:COC1=CC(=CC(=C1OC)OC)CC2=CN=C(NC2=O)N
Uses Degradation product/impurity of trimethoprim (T795615).

Technology Process of 4-Desamino-4-hydroxy trimethoprim

There total 4 articles about 4-Desamino-4-hydroxy trimethoprim which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 30.0%

: 70311-20-5
3-(3,4,5-trimethoxyphenyl)propionic acid ethyl ester

: 593-85-1,90332-86-8,3425-08-9
diguanidine carbonate

: 109-94-4
formic acid ethyl ester

: 92440-76-1
2-amino-4-hydroxy-5-(3,4,5-trimethoxybenzyl)pyrimidine

Guidance literature:: 3-(3,4,5-trimethoxyphenyl)propionic acid ethyl ester; formic acid ethyl ester; With sodium; In diethyl ether; toluene; at 0 ℃; for 24h;

diguanidine carbonate; With sodium methylate; In methanol; for 48h; Heating;