N-[2-(3,4-dimethoxyphenyl)ethyl]butanamide

Base Information

• Chemical Name: N-[2-(3,4-dimethoxyphenyl)ethyl]butanamide
• CAS No.: 81165-56-2
• Molecular Formula: C14H21 N O3
• Molecular Weight: 251.326
• Mol file: 81165-56-2.mol

Synonyms:Butyramide,N-(3,4-dimethoxyphenethyl)- (6CI); N-(3,4-Dimethoxyphenethyl)butyramide;N-Butanoyl-2-(3,4-dimethoxyphenyl)ethanamine;N-[2-(3,4-Dimethoxyphenyl)ethyl]butanamide; NSC 34979

Chemical Property of N-[2-(3,4-dimethoxyphenyl)ethyl]butanamide

Chemical Property:

• Vapor Pressure: 1.38E-07mmHg at 25°C
• Boiling Point: 429.6°Cat760mmHg
• Flash Point: 213.6°C
• Density: 1.037g/cm³

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of N-[2-(3,4-dimethoxyphenyl)ethyl]butanamide

There total 5 articles about N-[2-(3,4-dimethoxyphenyl)ethyl]butanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

2-(3,4-dimethoxyphenyl)-ethylamine (120-20-7) + butyric acid (107-92-6) → N-(3,4-Dimethoxyphenethyl)butyramide (81165-56-2)

Guidance literature:

2-(3,4-dimethoxyphenyl)-ethylamine; 4-formyl-3,5-dimethoxyphenoxy-Merrifield resin; With sodium tris(acetoxy)borohydride; In acetic acid; N,N-dimethyl-formamide; at 20 ℃; for 69h;

butyric acid; With benzotriazol-1-ol; dicyclohexyl-carbodiimide; In N,N-dimethyl-formamide; at 20 ℃; for 15h;

With dimethylsulfide; water; trifluoroacetic acid; In dichloromethane; at 20 ℃; for 15h;

DOI:10.1016/S0968-0896(99)00285-0

Reference yield: 90.0%

2-(3,4-dimethoxyphenyl)-ethylamine (120-20-7) + butyryl chloride (141-75-3) → N-(3,4-Dimethoxyphenethyl)butyramide (81165-56-2)

Guidance literature:

With triethylamine; In dichloromethane; at 0 ℃; for 2 - 3h;

Reference yield: 79.0%

butanoic acid anhydride (106-31-0) + 2-(3,4-dimethoxyphenyl)-ethylamine (120-20-7) → N-(3,4-Dimethoxyphenethyl)butyramide (81165-56-2)

Guidance literature:

With triethylamine; In ethyl acetate; at 20 ℃; for 1h;

DOI:10.1021/jm0607395

upstream raw materials:

2-(3,4-dimethoxyphenyl)-ethylamine

butyryl chloride

butanoic acid anhydride

butyric acid

Downstream raw materials:

1,2,3,4-tetrahydro-6,7-dimethoxy-2-(3,4-dimethoxybenzoyl)-1-propylidene-isoquinoline

N-<β-(3,4-dimethoxy-6-<1-oxobutyl>phenyl)ethyl>-3,4-dimethoxybenzamide

Refernces

• 1、 -. "3,4-DIHYDROISOQUINOLINIUM SALT DERIVATIVES". Page/Page column 74-75. . Retrieved 2008/06/13.
• 2、 Cui, Wenhua,Iwasa, Kinuko,Tokuda, Harukuni,Kashihara, Akiko,Mitani, Yosuke,Hasegawa, Tomoko,Nishiyama, Yumi,Moriyasu, Masataka,Nishino, Hoyoku,Hanaoka, Miyoji,Mukai, Chisato,Takeda, Kazuyoshi. "Potential cancer chemopreventive activity of simple isoquinolines, 1-benzylisoquinolines, and protoberberines". . p. 70 - 79. Retrieved 2008/02/04.