ethyl 4-methyl-5-oxo-1-phenyl-4,5-dihydro-1H-pyrazole-3-carboxylate

Base Information

• Chemical Name: ethyl 4-methyl-5-oxo-1-phenyl-4,5-dihydro-1H-pyrazole-3-carboxylate
• CAS No.: 60178-94-1
• Molecular Formula: C13H14 N2 O3
• Molecular Weight: 246.2619
• Mol file: 60178-94-1.mol

Synonyms:2-Pyrazoline-3-carboxylicacid, 4-methyl-5-oxo-1-phenyl-, ethyl ester (6CI); NSC 278752

Chemical Property of ethyl 4-methyl-5-oxo-1-phenyl-4,5-dihydro-1H-pyrazole-3-carboxylate

Chemical Property:

• Vapor Pressure: 7.77E-05mmHg at 25°C
• Boiling Point: 342°Cat760mmHg
• Flash Point: 160.6°C
• Density: 1.23g/cm³

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of ethyl 4-methyl-5-oxo-1-phenyl-4,5-dihydro-1H-pyrazole-3-carboxylate

There total 2 articles about ethyl 4-methyl-5-oxo-1-phenyl-4,5-dihydro-1H-pyrazole-3-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

diethyl oxalpropionate (759-65-9) + phenylhydrazine (100-63-0) → 4-methyl-5-oxo-1-phenyl-2,5-dihydro-1H-pyrazole-3-carboxylic acid ethyl ester (60178-94-1)

Guidance literature:

With sodium acetate; acetic acid; at 110 ℃;

DOI:10.1002/ejoc.202101005

Reference yield:

→ 4-methyl-5-oxo-1-phenyl-2,5-dihydro-1H-pyrazole-3-carboxylic acid ethyl ester (60178-94-1)

Guidance literature:

3-Methyl-2-oxo-bernsteinsaeure-diaethylester u. Phenyl-hydrazin;

DOI:10.1021/jo01055a532

Reference yield: 85.0%

2-diazocyclohexane-1,3-dione (1460-08-8) + 4-methyl-5-oxo-1-phenyl-2,5-dihydro-1H-pyrazole-3-carboxylic acid ethyl ester (60178-94-1) → ethyl 1-(6'-hydroxy-2'-oxo-2',3',4',5'-tetrahydro[1,1'-biphenyl]-2-yl)-4-methyl-5-oxo-2,5-dihydro-1H-pyrazole-3-carboxylate

Guidance literature:

With dichloro(pentamethylcyclopentadienyl)rhodium (III) dimer; acetic acid; silver(I) triflimide; In chloroform; at 70 ℃; for 3h; Schlenk technique; Sealed tube;

DOI:10.1002/ejoc.202101005

upstream raw materials:

diethyl oxalpropionate

phenylhydrazine

Refernces