Z-ASP(OTBU)-OH DCHA

Base Information

• Chemical Name: Z-ASP(OTBU)-OH DCHA
• CAS No.: 23632-70-4
• Molecular Formula: C28H44N2O6
• Molecular Weight: 504.667
• Mol file: 23632-70-4.mol

Synonyms:N-ALPHA-BENZYLOXYCARBONYL-L-ASPARTIC ACID BETA-TERT-BUTYL ESTER DICYCLOHEXYLAMINE;N-ALPHA-CARBOBENZOXY-L-ASPARTIC ACID ALPHA-T-BUTYL ESTER DICYCLOHEXYLAMONIUM SALT;N-ALPHA-CARBOBENZOXY-L-ASPARTIC ACID BETA-T-BUTYL ESTER DICYCLOHEXYLAMMONIUM SALT;N-CARBOBENZOXY-L-ASPARTIC-BETA-TERT-BUTYL ESTER DICYCLOHEXYLAMINE SALT;Z-L-ASP(TBU)-OH DCHA;Z-L-ASPARTIC ACID-ALPHA-T-BUTYL ESTER DCHA SALT;Z-L-ASPARTIC ACID ALPHA-T-BUTYL ESTER DICYCLOHEXYLAMMONIUM SALT;Z-L-ASPARTIC ACID BETA-T-BUTYL ESTER DICYCLOHEXYLAMMONIUM SALT

Chemical Property of Z-ASP(OTBU)-OH DCHA

Chemical Property:

• Vapor Pressure: 1.07E-18mmHg at 25°C
• Melting Point: 107-109°C
• Boiling Point: 666.9°Cat760mmHg
• Flash Point: 357.1°C
• PSA: 113.96000
• Density: g/cm³
• LogP: 6.12100
• Storage Temp.: 2-8°C
• Solubility.: DMSO (Slightly), Methanol (Sparingly, Heated)

Purity/Quality:

99% min ^*data from raw suppliers

N-Benzyloxycarbonyl-L-asparticAcidβ-tert-ButylEsterDicyclohexylamineSalt ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: Protected amino acid.

Technology Process of Z-ASP(OTBU)-OH DCHA

There total 2 articles about Z-ASP(OTBU)-OH DCHA which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

Z-L-Asp(β-O-t-Bu)-ONb (27486-72-2) → DCHA salt of the β-tert-butyl ester of N-benzyloxycarbonylaspartic acid (23632-70-4)

Guidance literature:

With tetrabutyl ammonium fluoride; In tetrahydrofuran; Ambient temperature;

DOI:10.1021/jo00018a052

Reference yield:

→ 4-tert-butyl hydrogen N-[(benzyloxy)carbonyl]-L-aspartate, compound with dicyclohexylamine (1:1) (23632-70-4)

Guidance literature:

α-t-Bu β-methyl-N-boc-L-aspn;

Reference yield: 100.0%

(S)-tryptophan methyl ester hydrochloride (7524-52-9,26988-71-6,5619-09-0,14907-27-8,41222-70-2,67557-19-1,109492-62-8) + DCHA salt of the β-tert-butyl ester of N-benzyloxycarbonylaspartic acid (23632-70-4) → Z-Asp(O-t-Bu)-Trp-OMe (98385-60-5)

Guidance literature:

With dicyclohexyl-carbodiimide; In dichloromethane; Ambient temperature; overnight;

DOI:10.1246/bcsj.58.2805

upstream raw materials:

Z-L-Asp(β-O-t-Bu)-ONb

Downstream raw materials:

Benzyloxycarbonyl-β-tert.-butyl-L-aspartyl-glycin-aethylester

(S)-2-((S)-2-Benzyloxycarbonylamino-3-tert-butoxycarbonyl-propionylamino)-3-methyl-butyric acid methyl ester

N-[N-[(phenylmethoxy)carbonyl]-L-α-aspartyl]-L-phenylalanine 4-(1,1-dimethylethyl) 1-methyl ester

Z-Asp(O-t-Bu)-Trp-OMe

Refernces