1H-Pyrrole-2-carboxamide,N,1-dimethyl-(9CI)

Base Information

• Chemical Name: 1H-Pyrrole-2-carboxamide,N,1-dimethyl-(9CI)
• CAS No.: 7151-19-1
• Molecular Formula: C7H10 N2 O
• Molecular Weight: 138.1671
• Hs Code.: 2933990090
• Mol file: 7151-19-1.mol

Synonyms:NSC70403

Chemical Property of 1H-Pyrrole-2-carboxamide,N,1-dimethyl-(9CI)

Chemical Property:

• Vapor Pressure: 0.000142mmHg at 25°C
• Boiling Point: 332.8°Cat760mmHg
• Flash Point: 155.1°C
• PSA: 34.03000
• Density: 1.08g/cm³
• LogP: 0.77560
• Storage Temp.: Room temperature.

Purity/Quality:

99% ^*data from raw suppliers

N-Methyl1-Methylpyrrole-2-carboxamide ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1H-Pyrrole-2-carboxamide,N,1-dimethyl-(9CI)

There total 4 articles about 1H-Pyrrole-2-carboxamide,N,1-dimethyl-(9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1-Methyl-2-pyrrolecarboxylic acid (6973-60-0) + methylamine hydrochloride (593-51-1) → N,1-dimethyl-1H-pyrrole-2-carboxamide (7151-19-1)

Guidance literature:

1-Methyl-2-pyrrolecarboxylic acid; methylamine hydrochloride; With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In acetonitrile; for 0.0833333h; Inert atmosphere;

With triethylamine; In acetonitrile; for 1.5h; Inert atmosphere;

DOI:10.1021/ja103776u

Reference yield:

N-Methylpyrrole (96-54-8) + bis(trichloromethyl) carbonate (32315-10-9) + methylamine (74-89-5) → N,1-dimethyl-1H-pyrrole-2-carboxamide (7151-19-1)

Guidance literature:

Yield given. Multistep reaction; 1.) Et₂O, 25 deg C, overnight, 2.) Et₂O, H₂O, 1 h;

DOI:10.1021/jm00021a009

Reference yield:

→ N,1-dimethyl-1H-pyrrole-2-carboxamide (7151-19-1)

Guidance literature:

bei der trocknen Destillation;

upstream raw materials:

N-Methylpyrrole

bis(trichloromethyl) carbonate

methylamine

1-Methyl-2-pyrrolecarboxylic acid

Downstream raw materials:

4-ethyl-1,6-dimethyl-5-phenyl-1H-pyrrolo[2,3-c]pyridin-7(6H)-one

N-methyl(1-methyl-1H-pyrrol-2-yl)methylanamine

Refernces

• 1、 Scott, Malcolm K.,Baxter, Ellen W.,Bennett, Debra J.,Boyd, Robert E.,Blum, Paul S.,et al.. "Piperazinylalkyl Heterocycles as Potential Antipsychotic Agents". . p. 4198 - 4210. Retrieved 2007/10/03.