Urapidil hydrochloride

Base Information

• Chemical Name: Urapidil hydrochloride
• CAS No.: 64887-14-5
• Molecular Formula: C20H29N5O3^.HCl
• Molecular Weight: 423.94
• Hs Code.: 3004909090
• Mol file: 64887-14-5.mol

Synonyms:2,4(1H,3H)-Pyrimidinedione,6-[[3-[4-(2-methoxyphenyl)-1-piperazinyl]propyl]amino]-1,3-dimethyl-,monohydrochloride (9CI);Urapidil hydrochloride;

Chemical Property of Urapidil hydrochloride

Chemical Property:

• Appearance/Colour: white to off-white crystalline powder
• Vapor Pressure: 4.22E-12mmHg at 25°C
• Melting Point: 156-158 °C
• Boiling Point: 549 °C at 760 mmHg
• Flash Point: 285.8 °C
• PSA: 71.74000
• LogP: 1.59470
• Storage Temp.: Desiccate at RT
• Solubility.: H2O: soluble

Purity/Quality:

99% ^*data from raw suppliers

Urapidil hydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xn
• Hazard Codes: Xn
• Statements: 22-36/37/38
• Safety Statements: 26-36

MSDS Files:

SDS file from LookChem

Useful:

• Description: Urapidil is an antagonist of α1-adrenergic receptors (α1-ARs) and a partial agonist of the serotonin (5-HT) receptor subtype 5-HT1A. It selectively binds to α1- over α2-ARs (IC50s = 0.74 and 42 μM, respectively) and to 5-HT1A over 5-HT1B and 5-HT2 receptors (IC50s = 0.4, 20.4, and >10 μM, respectively) in rat cortex. Urapidil inhibits cAMP accumulation induced by forskolin in calf hippocampus as a functional model for 5-HT1A receptors (EC50 = 390 nM). It is also a β1-AR antagonist that inhibits the positive chronotropic response induced by isoproterenol in isolated rat atria (pA2 = 6.05). Urapidil (1 μmol/kg, i.v.) lowers mean arterial pressure (MAP) in anesthetized cats, an effect that is reduced by central administration of the 5-HT1A receptor antagonist spiroxatrine.
• Uses: α1-Adrenergic antagonist; derivative of Uracil (U801000). Antihypertensive. Antihypertensive;Serotonergic receptor agonist a1-Adrenergic antagonist; derivative of Uracil. Antihypertensive