Methoxymethyl salicylate

Base Information

• Chemical Name: Methoxymethyl salicylate
• CAS No.: 575-82-6
• Molecular Formula: C9H10 O4
• Molecular Weight: 182.176
• European Community (EC) Number: 209-393-5
• UNII: JLO907D86Z
• DSSTox Substance ID: DTXSID10206112
• Nikkaji Number: J6.561G
• Wikidata: Q27281568
• Mol file: 575-82-6.mol

Synonyms:Methoxymethyl salicylate;mesotan;methoxymethyl 2-hydroxybenzoate;575-82-6;UNII-JLO907D86Z;Ericin;JLO907D86Z;EINECS 209-393-5;Benzoic acid, 2-hydroxy-, methoxymethyl ester;MEZOTAN;SALIMETHYL;SALMESTER;Salicylsauremethoxymethylester;DTXSID10206112;METHANOL, METHOXY-, SALICYLATE;SALICYLIC ACID, METHOXYMETHYL ESTER;Q27281568

Chemical Property of Methoxymethyl salicylate

Chemical Property:

• Vapor Pressure: 0.00204mmHg at 25°C
• Melting Point: 180-200 °C (decomp)
• Boiling Point: 281.8°Cat760mmHg
• PKA: 7.89±0.30(Predicted)
• Flash Point: 110.6°C
• PSA: 55.76000
• Density: 1.225g/cm³
• LogP: 1.15290
• XLogP3: 2.5
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 4
• Exact Mass: 182.05790880
• Heavy Atom Count: 13
• Complexity: 169

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COCOC(=O)C1=CC=CC=C1O

Technology Process of Methoxymethyl salicylate

There total 3 articles about Methoxymethyl salicylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

sodium salicylate (54-21-7) + chloromethyl methyl ether (107-30-2) → salicylic acid methoxymethyl ester (575-82-6)

Guidance literature:

With benzene; at 40 ℃;

Reference yield:

Dimethoxymethane (109-87-5) + salicylic acid (69-72-7,25496-36-0,8052-31-1) → salicylic acid methoxymethyl ester (575-82-6)

Guidance literature:

Multistep reaction; (i) Zn, BrCH₂CO₂Et, (ii) /BRN= 1697025/, AcCl;

DOI:10.1055/s-1977-24478

Reference yield:

sodium salicylate (54-21-7) + chloromethyl methyl ether (107-30-2) + benzene (71-43-2,26181-88-4,54682-86-9,13967-78-7,174973-66-1) → salicylic acid methoxymethyl ester (575-82-6)

Guidance literature:

at 40 ℃;

upstream raw materials:

sodium salicylate

chloromethyl methyl ether

benzene

Dimethoxymethane

Downstream raw materials:

methanol

formaldehyd

salicylic acid