3,5-Difluorobenzyl bromide

Base Information

• Chemical Name: 3,5-Difluorobenzyl bromide
• CAS No.: 141776-91-2
• Molecular Formula: C7H5BrF2
• Molecular Weight: 207.018
• Hs Code.: 29039990
• Mol file: 141776-91-2.mol

Synonyms:1-Bromomethyl-3,5-difluorobenzene;

Chemical Property of 3,5-Difluorobenzyl bromide

Chemical Property:

• Appearance/Colour: Colorless to light yellow liquid
• Vapor Pressure: 2.49E-07mmHg at 25°C
• Refractive Index: n20/D 1.521(lit.)
• Boiling Point: 205.1 °C at 760 mmHg
• Flash Point: 81.7 °C
• PSA: 0.00000
• Density: 1.6 g/cm³
• LogP: 2.85970
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• Sensitive.: Lachrymatory

Purity/Quality:

98%,99%, ^*data from raw suppliers

3,5-Difluorobenzyl Bromide ^*data from reagent suppliers

Safty Information:

• Pictogram(s): C
• Hazard Codes: C,Xi
• Statements: 34-36-43
• Safety Statements: 26-36/37/39-45-27-36/37

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

Technology Process of 3,5-Difluorobenzyl bromide

There total 4 articles about 3,5-Difluorobenzyl bromide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3,5-difluorobenzyl alcohol (79538-20-8) → 1-bromomethyl-3,5-difluoro-benzene (141776-91-2)

Guidance literature:

With sulfuric acid; hydrogen bromide;

Reference yield:

2-[4-(trifluoromethyl)phenyl]ethyl bromide (130365-87-6) + C7H5F2(1+) → 1-bromomethyl-3,5-difluoro-benzene (141776-91-2) + C9H8F3(1+)

Guidance literature:

at 26.85 ℃; Thermodynamic data; gas phase; low pressure;

DOI:10.1246/bcsj.71.1401

Reference yield:

3-(2-bromoethyl)benzonitrile (942282-39-5) + C7H5F2(1+) → 1-bromomethyl-3,5-difluoro-benzene (141776-91-2) + C9H8N(1+)

Guidance literature:

at 26.85 ℃; Further Variations:; Reaction partners; Thermodynamic data; gas phase; low pressure;

DOI:10.1246/bcsj.71.1401

upstream raw materials:

2-[4-(trifluoromethyl)phenyl]ethyl bromide

3-(2-bromoethyl)benzonitrile

3,5-difluorobenzyl alcohol

Downstream raw materials:

methyl (2S,3S)-2-(3,5-difluorobenzyloxy)-3-methylpentanoate

Refernces

• 1、 Mustanir,Mishima, Masaaki,Fujio, Mizue,Tsuno, Yuho. "Thermodynamic Stabilities of Phenonium Ions Based on Bromide-Transfer Equilibria in the Gas Phase". . p. 1401 - 1407. Retrieved 2007/10/03.