5-AMINOBENZOTRIAZOLE

Base Information

• Chemical Name: 5-AMINOBENZOTRIAZOLE
• CAS No.: 3325-11-9
• Molecular Formula: C6H6 N4
• Molecular Weight: 134.14
• Hs Code.: 2933990090
• Mol file: 3325-11-9.mol

Synonyms:1H-Benzotriazol-5-amine(9CI); Benzotriazole, 5-amino- (6CI,7CI); 1H-1,2,3-Benzotriazol-5-amine;1H-Benzo[d][1,2,3]triazol-5-amine; 1H-Benzo[d][1,2,3]triazol-6-amine;5(6)-Aminobenzotriazole; 5-Aminobenzotriazole; 5-Aminobenztriazole;6-Aminobenzotriazole

Chemical Property of 5-AMINOBENZOTRIAZOLE

Chemical Property:

• Vapor Pressure: 3.29E-06mmHg at 25°C
• Melting Point: 152-154°C
• Boiling Point: 387.4°Cat760mmHg
• PKA: 9.61±0.40(Predicted)
• Flash Point: 216.5°C
• PSA: 67.59000
• Density: 1.48g/cm³
• LogP: 1.12130
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• Water Solubility.: Insoluble in water.

Purity/Quality:

99% ^*data from raw suppliers

1H-1,2,3-Benzotriazol-5-amine ^*data from reagent suppliers

Safty Information:

• Pictogram(s): R20/21/22:Harmful by inhalation, in contact with skin and if swallowed.
• Hazard Codes: Xi
• Statements: 20/21/22-36/37/38
• Safety Statements: 22-36/37-26

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 5-Amino-1H-benzotriazole is used as azole building block.

Technology Process of 5-AMINOBENZOTRIAZOLE

There total 7 articles about 5-AMINOBENZOTRIAZOLE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

5-nitrobenzotriazole (2338-12-7) → 5-aminobenzotriazole (3325-11-9)

Guidance literature:

With hydrogen; palladium on activated charcoal; In tetrahydrofuran; under 2378.9 Torr;

Reference yield: 60.0%

5-nitro-1H-benzotriazole hydrochloride → 5-aminobenzotriazole (3325-11-9)

Guidance literature:

With water; hydrogen iodide; at 90 ℃; for 3h;

DOI:10.1021/jp102848y

Reference yield: 40.0%

(Z)-2-(2H-Benzotriazol-5-ylamino)-but-2-enedioic acid dimethyl ester → 5-aminobenzotriazole (503183-58-2,3325-11-9)

Guidance literature:

In diethyl ether; for 0.5h; Heating;

upstream raw materials:

5-nitrobenzotriazole

4-Nitrophenylene-1,2-diamine

Downstream raw materials:

5-iodo-1H-benzotriazole

Refernces

• 1、 W?sik, Romualda,?ebska, Maja,Felczak, Krzysztof,Poznański, Jaros?aw,Shugar, David. "Relative role of halogen bonds and hydrophobic interactions in inhibition of human protein kinase CK2α by tetrabromobenzotriazole and some C(5)-substituted analogues". experimental part. p. 10601 - 10611. Retrieved 2011/01/03.
• 2、 Sanna, Paolo,Nuvole, Antonio,Sequi, Piera Attilia,Paglietti, Giuseppe. "Addition reactions of 5-aminobenzotriazoles with dimethyl acetylenedicarboxylate (DMAD). Formation of (Z/E) Michael adducts, (benzotriazol-5-yl)-2-pyridones, a triazolo-9,10-dihydrobenzoazepine and a triazolo-2-oxindole". . p. 259 - 280. Retrieved 2007/10/02.