6-CHLORO (1H)INDAZOLE

Base Information

• Chemical Name: 6-CHLORO (1H)INDAZOLE
• CAS No.: 698-25-9
• Molecular Formula: C7H5ClN2
• Molecular Weight: 152.583
• Hs Code.: 2933990090
• Mol file: 698-25-9.mol

Synonyms:6-Chloroindazole;NSC 92743;

Chemical Property of 6-CHLORO (1H)INDAZOLE

Chemical Property:

• Vapor Pressure: 0.00116mmHg at 25°C
• Melting Point: 174-177℃
• Refractive Index: 1.703
• Boiling Point: 309.5 °C at 760 mmHg
• PKA: 12.82±0.40(Predicted)
• Flash Point: 169.9 °C
• PSA: 28.68000
• Density: 1.425 g/cm³
• LogP: 2.21630
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

98%,99%, ^*data from raw suppliers

6-Chloro-1H-indazole ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xn
• Hazard Codes: Xn
• Statements: 22

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 6-CHLORO (1H)INDAZOLE

There total 10 articles about 6-CHLORO (1H)INDAZOLE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

tert-butyl (5-chloro-2-methylphenyl)azo sulfide → 6-chloro-1H-indazole (698-25-9)

Guidance literature:

With potassium tert-butylate; In dimethyl sulfoxide; for 24h; Ambient temperature;

DOI:10.1016/S0040-4020(01)87030-7

Reference yield: 90.0%

C7H6ClN2(1+)*BF4(1-) → 6-chloro-1H-indazole (698-25-9)

Guidance literature:

With potassium acetate; 18-crown-6 ether; In chloroform; for 1h;

Reference yield: 65.0%

5-chloro-2-methyl-benzenamine (95-79-4) → 6-chloro-1H-indazole (698-25-9)

Guidance literature:

5-chloro-2-methyl-benzenamine; With hydrogenchloride; sodium nitrite; In water; at 0 ℃; for 0.5h;

With sodium tetrafluoroborate; In water; at 0 ℃; for 0.666667h;

With potassium acetate; In chloroform; at 20 ℃; for 4h;

DOI:10.1016/j.bmc.2015.02.004

upstream raw materials:

1-Acetyl-6-chlorindazol

5-chloro-2-methyl-benzenamine

acetic anhydride

4-chloro-2-fluorobenzaldehyde

Downstream raw materials:

1-Acetyl-6-chlorindazol

4-amino-2-[6-chloro-1-(3,3,4,4,4-pentafluorobutyl)-1H-indazol-3-yl]-5-methyl-5-phenyl-5,7-dihydro-6H-pyrrolo[2,3-d]pyrimidin-6-one

6-chloro-1H-indazole-3-carbonitrile

2-[6-chloro-1-(3,3,4,4,4-pentafluorobutyl)-1H-indazol-3-yl]-5-methyl-4-(methylamino)-5-phenyl-5,7-dihydro-6H-pyrrolo[2,3-d]pyrimidin-6-one

Refernces

• 1、 Du, Shijie,Li, Zhonghao,Tian, Zaimin,Xu, Lu. "Synthesis, antifungal activity and qsar of novel pyrazole amides as succinate dehydrogenase inhibitors". . p. 74 - 85. Retrieved 2018/01/26.
• 2、 Song, Pinrao,Chen, Ming,Ma, Xiaodong,Xu, Lei,Liu, Tao,Zhou, Yubo,Hu, Yongzhou. "Identification of novel inhibitors of Aurora A with a 3-(pyrrolopyridin-2-yl)indazole scaffold". . p. 1858 - 1868. Retrieved 2015/03/18.