2-Tert-butylimidazo[1,2-a]pyridine

Base Information

• Chemical Name: 2-Tert-butylimidazo[1,2-a]pyridine
• CAS No.: 406207-65-6
• Molecular Formula: C11H14N2
• Molecular Weight: 174.246
• Hs Code.: 2933990090
• DSSTox Substance ID: DTXSID80428001
• Nikkaji Number: J1.615.165C
• Wikidata: Q72503413
• Mol file: 406207-65-6.mol

Synonyms:2-tert-butylimidazo[1,2-a]pyridine;406207-65-6;2-(tert-Butyl)imidazo[1,2-a]pyridine;2-TERT-BUTYL-IMIDAZO[1,2-A]PYRIDINE;MFCD00269176;2-TERT-BUTYL-IMIDAZO[1,2-A]-PYRIDINE;SCHEMBL10129490;DTXSID80428001;2-t-butylimidazo[1,2-a]pyridine;BBL021300;STK894006;AKOS005144370;FT-0716609;E84649

Chemical Property of 2-Tert-butylimidazo[1,2-a]pyridine

Chemical Property:

• Refractive Index: 1.558
• PSA: 17.30000
• Density: 1.01 g/cm³
• LogP: 2.63180
• Storage Temp.: 2-8°C
• XLogP3: 3.5
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 1
• Exact Mass: 174.115698455
• Heavy Atom Count: 13
• Complexity: 183

Purity/Quality:

98%min ^*data from raw suppliers

2-tert-butylimidazo[1,2-a]pyridine ^*data from reagent suppliers

Safty Information:

• Pictogram(s): T
• Hazard Codes: T

MSDS Files:

Useful:

• Canonical SMILES: CC(C)(C)C1=CN2C=CC=CC2=N1

Technology Process of 2-Tert-butylimidazo[1,2-a]pyridine

There total 2 articles about 2-Tert-butylimidazo[1,2-a]pyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

2-aminopyridine (504-29-0) + 1-Bromopinacolon (5469-26-1) → 2-tert-butyl-imidazolium[1,2-a]pyridine (406207-65-6)

Guidance literature:

In water; at 20 ℃; for 8h; Green chemistry;

DOI:10.14233/ajchem.2017.20533

Reference yield: 67.0%

2-aminopyridine (504-29-0) + 3,3-dimethyl-butan-2-one (75-97-8) → 2-tert-butyl-imidazolium[1,2-a]pyridine (406207-65-6)

Guidance literature:

With copper(l) iodide; boron trifluoride diethyl etherate; oxygen; In N,N-dimethyl-formamide; at 60 ℃; for 24h;

DOI:10.1002/adsc.201300456

Reference yield: 90.0%

acetophenone (98-86-2) + 2-tert-butyl-imidazolium[1,2-a]pyridine (406207-65-6) → 1-(2-(tert-butyl)imidazo[1,2-a]pyridin-3-yl)-2-phenylethane-1,2-dione

Guidance literature:

With oxygen; copper diacetate; acetic acid; In toluene; at 140 ℃; for 12h; regioselective reaction; Schlenk technique; Sealed tube;

DOI:10.1002/adsc.201500803

upstream raw materials:

2-aminopyridine

1-Bromopinacolon

3,3-dimethyl-butan-2-one

Downstream raw materials:

2-tert-butyl-3-(3,5-dimethylphenyl)imidazo[1,2-a]pyridine

2-tert-butyl-3-(4-chlorophenyl)imidazo[1,2-a]pyridine

2-tert-butyl-3-(3-chlorophenyl)imidazo[1,2-a]pyridine

2-tert-butyl-3-(2-chlorophenyl)imidazo[1,2-a]pyridine

Refernces

• 1、 Kim, Wansoo,Kim, Hun Young,Oh, Kyungsoo. "Oxidation Potential-Guided Electrochemical Radical-Radical Cross-Coupling Approaches to 3-Sulfonylated Imidazopyridines and Indolizines". . p. 15973 - 15991. Retrieved 2021/07/26.
• 2、 Kushwaha, Narva Deshwar,Mondal, Somnath,Sharma, Renu,Kumar, Naresh. "Synthesis and characterization of Imidazo [1,2-a]pyridines and Zolimidine". . p. 1495 - 1498. Retrieved 2017/05/29.