2-Furanpropanol

Base Information

• Chemical Name: 2-Furanpropanol
• CAS No.: 26908-23-6
• Molecular Formula: C7H10 O2
• Molecular Weight: 126.155
• European Community (EC) Number: 837-830-5
• NSC Number: 18514
• DSSTox Substance ID: DTXSID50949697
• Nikkaji Number: J49.598K
• Wikidata: Q82927627
• Mol file: 26908-23-6.mol

Synonyms:2-FURANPROPANOL;3-(furan-2-yl)propan-1-ol;26908-23-6;3-furan-2-yl-propan-1-ol;NSC18514;2-Furan-1-propanol;SCHEMBL837175;DTXSID50949697;BBA90823;NSC-18514;FT-0715590;EN300-125520;F88365

Chemical Property of 2-Furanpropanol

Chemical Property:

• Vapor Pressure: 0.151mmHg at 25°C
• Boiling Point: 157.2°Cat760mmHg
• Flash Point: 48.9°C
• Density: 1.052g/cm³
• XLogP3: 1.4
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 3
• Exact Mass: 126.068079557
• Heavy Atom Count: 9
• Complexity: 73.3

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=COC(=C1)CCCO

Technology Process of 2-Furanpropanol

There total 29 articles about 2-Furanpropanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

(E)-3-(2-furanyl)-2-propen-1-ol (27393-97-1,79380-02-2) → 3-furan-2-yl-propan-1-ol (26908-23-6)

Guidance literature:

With hydrogen; palladium on activated charcoal; In methanol;

DOI:10.1016/j.tetlet.2008.04.077

Reference yield: 96.0%

ethyl 3-(furan-2-yl)propanoate (10031-90-0) → 3-furan-2-yl-propan-1-ol (26908-23-6)

Guidance literature:

With lithium aluminium tetrahydride; In diethyl ether;

DOI:10.1016/j.tetlet.2005.06.137

Reference yield: 96.0%

3-(2-furyl)propanoic acid (935-13-7) → 3-furan-2-yl-propan-1-ol (26908-23-6)

Guidance literature:

With borane-THF; In tetrahydrofuran; at 20 ℃; for 14h; Inert atmosphere;

DOI:10.1002/chem.201404502

upstream raw materials:

3-furan-2-yl-propenal

(E)-3-(2-furanyl)-2-propen-1-ol

(E)-3-(2-furanyl)-2-propenal

3-(2-furyl)propanoic acid

Downstream raw materials:

3-(tetrahydrofuran-2-yl)propan-1-ol

heptane-1,4,7-triol

1,6-dioxa[4,4]spirononane

Refernces

• 1、 D'Onofrio, Franco,Piancatelli, Giovanni,Nicolai, Massimo. "Photo-oxidation of 2-furyl-alkyl-phosphonates: Synthesis of new cyclopentenone derivatives". . p. 4083 - 4088. Retrieved 1995.
• 2、 Boullosa, Seila,Gándara, Zoila,Pérez, Manuel,Gómez, Generosa,Fall, Yagamare. "The furan approach to thiacyclic compounds. Stereoselective synthesis of 2,3-disubstituted tetrahydrothiopyrans". . p. 4040 - 4042. Retrieved 2008.
• 3、 Lofstrand, Verner A.,McIntosh, Kyle C.,Almehmadi, Yaseen A.,West. "Strain-activated diels-alder trapping of 1,2-cyclohexadienes: Intramolecular capture by pendent furans". . p. 6231 - 6234. Retrieved 2019.
• 4、 Nicolaou,Nilewski, Christian,Hale, Christopher R. H.,Ahles, Christopher F.,Chiu, Chiao An,Ebner, Christian,Elmarrouni, Abdelatif,Yang, Lifeng,Stiles, Katherine,Nagrath, Deepak. "Synthesis and Biological Evaluation of Dimeric Furanoid Macroheterocycles: Discovery of New Anticancer Agents". . p. 4766 - 4770. Retrieved 2015.
• 5、 Gu, Yiting,Lisnyak, Vladislav G.,Norton, Jack R.,Salahi, Farbod,Snyder, Scott A.,Zhou, Zhiyao. "Highly Selective Hydrogenation of C═C Bonds Catalyzed by a Rhodium Hydride". supporting information. p. 9657 - 9663. Retrieved 2021/07/19.
• 6、 Aleku, Godwin A.,Leys, David,Roberts, George W.. "Biocatalytic reduction of α,β-unsaturated carboxylic acids to allylic alcohols". . p. 3927 - 3939. Retrieved 2020/07/09.