Methyl amino(oxo)acetate

Base Information

• Chemical Name: Methyl amino(oxo)acetate
• CAS No.: 62155-27-5
• Molecular Formula: C3H5NO3
• Molecular Weight: 103.078
• Hs Code.: 2924199090
• NSC Number: 117382
• DSSTox Substance ID: DTXSID80977746
• Nikkaji Number: J24.724C
• Wikidata: Q82963035
• Mol file: 62155-27-5.mol

Synonyms:methyl amino(oxo)acetate;62155-27-5;Acetic acid aminooxo methyl ester;methyl 2-amino-2-oxoacetate;methyl oxamate;Acetic acid, aminooxo-, methyl ester;NSC117382;methyl aminooxoacetate;SCHEMBL971189;DTXSID80977746;AKOS006273085;NSC-117382

Chemical Property of Methyl amino(oxo)acetate

Chemical Property:

• Vapor Pressure: 1.34mmHg at 25°C
• Boiling Point: 172.3°Cat760mmHg
• Flash Point: 83.5°C
• PSA: 69.39000
• Density: 1.251g/cm³
• LogP: -0.65500
• XLogP3: -0.6
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 2
• Exact Mass: 103.026943022
• Heavy Atom Count: 7
• Complexity: 98.4

Purity/Quality:

98%min ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COC(=O)C(=O)N

Technology Process of Methyl amino(oxo)acetate

There total 11 articles about Methyl amino(oxo)acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

methanol (67-56-1) + acetoacetamido (5977-14-0) → methyl 2-amino-2-oxoacetate (62155-27-5)

Guidance literature:

With [bis(acetoxy)iodo]benzene; copper(l) chloride; at 25 ℃; for 3h;

DOI:10.1002/adsc.201800616

Reference yield: 60.0%

methanol (67-56-1) + diisopropenyl oxalate (148705-17-3) → methyl 2-amino-2-oxoacetate (62155-27-5)

Guidance literature:

With ammonia; for 5h; Ambient temperature;

DOI:10.1016/S0040-4020(01)86342-0

Reference yield:

dimethyl iminodiacetate (6096-81-7) → dimethyloxalylglycine (89464-63-1) + methyl 2-amino-2-oxoacetate (62155-27-5)

Guidance literature:

With oxygen; fullerene-C₆₀; [5,6]fullerene-C₇₀; In toluene; at 60 ℃; Irradiation;

DOI:10.1021/jo015749m

upstream raw materials:

Dimethyl oxalate

methanol

diisopropenyl oxalate

methyl bromonitroacetate

Downstream raw materials:

methyl cyanoformate

dichloro-methoxy-acetic acid amide

[(1RS,2RS)-2-hydroxymethyl-2-(4-nitro-phenyl)-ethyl]-oxalamide

Refernces

• 1、 Cheng,Gan,Shi,Wei. "A novel [2 + 3] cycloaddition reaction: Singlet oxygen mediated formation of 1,3-dipole from iminodiacetic acid dimethyl ester and its addition to maleimides". . p. 6369 - 6374. Retrieved 2001.
• 2、 Neveux, Muriel,Bruneau, Christian,Lecolier, Serge,Dixneuf, Pierre H.. "Novel syntheses of oxamides, oxamates and oxalates from diisopropenyl oxalate". . p. 2629 - 2640. Retrieved 2007/10/02.