Sarcosine hydrochloride

Base Information

• Chemical Name: Sarcosine hydrochloride
• CAS No.: 637-96-7
• Molecular Formula: C3H8ClNO2
• Molecular Weight: 125.555
• Hs Code.: 29224985
• European Community (EC) Number: 211-310-2
• UNII: W50V8R1ZE9
• DSSTox Substance ID: DTXSID5060930
• Wikidata: Q27292305
• Mol file: 637-96-7.mol

Synonyms:Magnesium Sarcosylate;Methylglycine;N Methylglycine;N-Methylglycine;Sarcosinate, Sodium;Sarcosine;Sarcosine Hydrochloride;Sarcosine Monosodium Salt;Sarcosylate, Magnesium;Sodium Sarcosinate

Chemical Property of Sarcosine hydrochloride

Chemical Property:

• Appearance/Colour: white adhering crystalline powder
• Vapor Pressure: 0.184mmHg at 25°C
• Melting Point: 173-175 °C (lit.)
• Boiling Point: 195.1 °C at 760 mmHg
• Flash Point: 71.8 °C
• PSA: 49.33000
• Density: 1.48 g/cm3
• LogP: 0.48330
• Storage Temp.: Inert atmosphere,Room Temperature
• Water Solubility.: Soluble in water.
• Hydrogen Bond Donor Count: 3
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 2
• Exact Mass: 125.0243562
• Heavy Atom Count: 7
• Complexity: 52.8

Purity/Quality:

99% ^*data from raw suppliers

2-(Methylamino)aceticacidhydrochloride ^*data from reagent suppliers

Safty Information:

• Safety Statements: 24/25

MSDS Files:

SDS file from LookChem

Useful:

• Chemical Classes: Biological Agents -> Amino Acids and Derivatives
• Canonical SMILES: CNCC(=O)O.Cl
• Uses: Sarcosine hydrochloride is used in organic synthesis.

Technology Process of Sarcosine hydrochloride

There total 1 articles about Sarcosine hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 63.0%

chloroacetic acid (79-11-8) + methylamine (74-89-5) → sarcosine hydrochloride (637-96-7)

Guidance literature:

chloroacetic acid; methylamine; With sodium hydrogencarbonate; In water; for 0.5h;

With hydrogenchloride; In water; at 35 ℃; for 24h; pH=2;

DOI:10.1016/j.ica.2015.03.006

Reference yield: 100.0%

4-(5-(((4-fluorophenyl)(isopropyl)amino)methyl)thiophen-2-yl)benzaldehyde (1220972-78-0) + sarcosine hydrochloride (637-96-7) → methyl-2-((4-(5-(((4-fluorophenyl)(isopropyl)amino)methyl)thiophen-2-yl)benzyl)(methyl)amino)acetate (1220972-79-1)

Guidance literature:

With sodium triacetoxy borohydride; acetic acid; N-ethyl-N,N-diisopropylamine; In 1,2-dichloro-ethane; at 20 ℃;

Reference yield: 90.0%

sarcosine hydrochloride (637-96-7) + 3,4-dichlorophenyl isocyanate (34893-92-0) → 3-(3,5-dichlorophenyl)-1-methyl-2,4-imidazolidinedione (27387-90-2)

Guidance literature:

sarcosine hydrochloride; With triethylamine; In dichloromethane; at 20 ℃; for 1.5 - 2h;

3,4-dichlorophenyl isocyanate; In dichloromethane; at 0 - 25 ℃; for 12.5 - 15h;

upstream raw materials:

chloroacetic acid

methylamine

Downstream raw materials:

1-Methyl-4-(2-nitro-phenyl)-1H-pyrrole-2-carboxylic acid ethyl ester

N-(9-fluorenylmethoxycarbonyl)sarcosine

methyl-2-((4-(5-(((4-fluorophenyl)(isopropyl)amino)methyl)thiophen-2-yl)benzyl)(methyl)amino)acetate

3-(3,5-dichlorophenyl)-1-methyl-2,4-imidazolidinedione

Refernces