2-Ethoxyquinoline

Base Information

• Chemical Name: 2-Ethoxyquinoline
• CAS No.: 46185-83-5
• Molecular Formula: C11H11 N O
• Molecular Weight: 173.214
• Hs Code.: 2933499090
• DSSTox Substance ID: DTXSID90963519
• Nikkaji Number: J1.086.818A
• Wikidata: Q82945390
• Mol file: 46185-83-5.mol

Synonyms:2-Ethoxyquinoline;46185-83-5;2-ethoxy-quinoline;SCHEMBL887723;DTXSID90963519;AZJQQNWSSLCLJN-UHFFFAOYSA-N;MFCD00234738;AKOS006274462;BS-28538

Chemical Property of 2-Ethoxyquinoline

Chemical Property:

• Vapor Pressure: 0.0106mmHg at 25°C
• Boiling Point: 271.6°Cat760mmHg
• Flash Point: 99.6°C
• PSA: 31.35000
• Density: 1.101g/cm³
• LogP: 2.64210
• Storage Temp.: Room temperature.
• XLogP3: 2.4
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 2
• Exact Mass: 173.084063974
• Heavy Atom Count: 13
• Complexity: 160

Purity/Quality:

98.5% ^*data from raw suppliers

2-Ethoxy-8-methoxyquinoline 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CCOC1=NC2=CC=CC=C2C=C1

Technology Process of 2-Ethoxyquinoline

There total 6 articles about 2-Ethoxyquinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.8%

Quinoline N-oxide (1613-37-2) + ethanol (64-17-5) → 2-ethoxyquinoline (46185-83-5) + 2-quinolone (59-31-4,70254-42-1,493-62-9)

Guidance literature:

With triethylamine; p-toluenesulfonyl chloride; for 12h; Ambient temperature;

Reference yield: 80.0%

Quinoline N-oxide (1613-37-2) + p-toluenesulfonyl chloride (98-59-9) → 2-ethoxyquinoline (46185-83-5) + 2-(4-methylbenzenesulfonyl)quinoline (62141-43-9)

Guidance literature:

With diisopropyl hydrogenphosphonate; potassium hydroxide; In ethanol; at 20 ℃; for 1h;

DOI:10.1039/c5cc04484g

Reference yield: 5.0%

Quinoline N-oxide (1613-37-2) + diethyl cyanophosphonate (2942-58-7) → quinoline-2-carbonitrile (1436-43-7) + 2-ethoxyquinoline (46185-83-5)

Guidance literature:

With triethylamine; In acetonitrile; for 18h; Heating;

upstream raw materials:

2-quinolone

ethyl iodide

2-Chloroquinoline

ethanolate

Downstream raw materials:

ethene

2-quinolone

1-Ethyl-1,2-dihydrochinolin-2-on

chloroethane

Refernces

• 1、 Hayashida, Mitsuo,Honda, Haruyoshi,Hamana, Masatomo. "DEOXYGENATIVE 2-ALKOXYLATION OF QUINOLINE 1-OXIDE". . p. 1325 - 1331. Retrieved 2007/10/02.
• 2、 Harusawa, Shinya,Hamada, Yasumasa,Shioiri, Takayuki. "NEW METHODS AND REAGENTS IN ORGANIC SYNTHESIS. 12. REACTION OF DIETHYL PHOSPHOROCYANIDATE (DEPC) WITH AROMATIC AMINE OXIDES. A MODIFIED REISSERT-HENZE REACTION". . p. 981 - 984. Retrieved 2007/10/02.