tert-butyl ethyl sulfoxide

Base Information

• Chemical Name: tert-butyl ethyl sulfoxide
• CAS No.: 25432-20-6
• Molecular Formula: C6H14 O S
• Molecular Weight: 134.2398
• Mol file: 25432-20-6.mol

Synonyms:Sulfoxide,tert-butyl ethyl (6CI,8CI); Sulfoxide, tert-butyl ethyl (7CI); Ethyl tert-butylsulfoxide; NSC 251030; tert-Butyl ethyl sulfoxide

Chemical Property of tert-butyl ethyl sulfoxide

Chemical Property:

• Vapor Pressure: 0.114mmHg at 25°C
• Boiling Point: 227.9°Cat760mmHg
• Flash Point: 91.7°C
• Density: 0.978g/cm³

Purity/Quality:

99%min ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of tert-butyl ethyl sulfoxide

There total 6 articles about tert-butyl ethyl sulfoxide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

2-(ethylthio)-2-methyl-propane (14290-92-7) → tert-butyl ethyl sulfoxide (25432-20-6)

Guidance literature:

With propan-1-ol; dihydrogen peroxide; In methanol; for 2h;

DOI:10.1055/s-1990-27059

Reference yield: 40.0%

tert-butyl methyl sulfoxide (14094-11-2) + methyl iodide (74-88-4) → tert-butyl ethyl sulfoxide (25432-20-6)

Guidance literature:

tert-butyl methyl sulfoxide; With n-butyllithium; diisopropylamine; In tetrahydrofuran; hexane; at -78 - 0 ℃;

methyl iodide; In tetrahydrofuran; at 22 ℃; for 1h;

DOI:10.1021/acs.orglett.0c03160

Reference yield:

tert-butyl methyl sulphide (6163-64-0) → tert-butyl ethyl sulfoxide (25432-20-6)

Guidance literature:

Multi-step reaction with 2 steps

1.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 1 h / 0 °C

2.1: n-butyllithium; diisopropylamine / hexane; tetrahydrofuran / -78 - 0 °C

2.2: 1 h / 22 °C

With n-butyllithium; diisopropylamine; 3-chloro-benzenecarboperoxoic acid; In tetrahydrofuran; hexane; dichloromethane;

DOI:10.1021/acs.orglett.0c03160

upstream raw materials:

methanol

tert.-butylhydroperoxide

2-(ethylthio)-2-methyl-propane

dibenzyl selenoxide

Downstream raw materials:

3-tert-Butylsulfinyl-1-phenyl-butanol-1

Refernces

• 1、 Drabowicz, Jozef,Lyzwa, Piotr,Popielarczyk, Miroslaw,Mikolajczyk, Marian. "A Convenient Procedure for the Oxidation of Sterically Hindered Sulfides to Sulfoxides". . p. 937 - 938. Retrieved 2007/10/02.