1-(benzyloxy)-4-(broMoMethyl)-2-Methoxybenzene

Base Information

• Chemical Name: 1-(benzyloxy)-4-(broMoMethyl)-2-Methoxybenzene
• CAS No.: 72724-00-6
• Molecular Formula: C15H15 Br O2
• Molecular Weight: 307.187
• Mol file: 72724-00-6.mol

Synonyms:1-(Benzyloxy)-4-(bromomethyl)-2-methoxybenzene;3-Methoxy-4-benzyloxybenzyl bromide; 4-(Benzyloxy)-3-methoxybenzyl bromide; NSC295383

Chemical Property of 1-(benzyloxy)-4-(broMoMethyl)-2-Methoxybenzene

Chemical Property:

• Vapor Pressure: 5.86E-06mmHg at 25°C
• Boiling Point: 390.7°Cat760mmHg
• Flash Point: 167.6°C
• PSA: 18.46000
• Density: 1.349g/cm³
• LogP: 4.16910

Purity/Quality:

99% ^*data from raw suppliers

1-Benzyloxy-4-bromomethyl-2-methoxybenzene 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-(benzyloxy)-4-(broMoMethyl)-2-Methoxybenzene

There total 14 articles about 1-(benzyloxy)-4-(broMoMethyl)-2-Methoxybenzene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

4-benzyloxy-3-methoxybenzyl alcohol (33693-48-0) → 1-(benzyloxy)-4-(bromomethyl)-2-methoxybenzene (72724-00-6)

Guidance literature:

With phosphorus tribromide; In diethyl ether;

DOI:10.1055/s-0031-1290658

Reference yield: 93.0%

4-benzyl-3-methoxybenzyl alcohol → 1-(benzyloxy)-4-(bromomethyl)-2-methoxybenzene (72724-00-6)

Guidance literature:

With phosphorus tribromide; In diethyl ether; at 0 ℃; for 0.333333h; Inert atmosphere;

DOI:10.1039/d1ob01653a

Reference yield:

3-methoxy-4-(phenylmethoxy)benzaldehyde (2426-87-1) → 1-(benzyloxy)-4-(bromomethyl)-2-methoxybenzene (72724-00-6)

Guidance literature:

Multi-step reaction with 2 steps

1: NaBH₄ / tetrahydrofuran; ethanol / 0 - 20 °C

2: PBr₃ / CH₂Cl₂ / 0 °C

With sodium tetrahydroborate; phosphorus tribromide; In tetrahydrofuran; ethanol; dichloromethane;

DOI:10.1021/jm061462b

upstream raw materials:

4-benzyloxy-3-methoxybenzyl alcohol

3-methoxy-4-(phenylmethoxy)benzaldehyde

benzyl bromide

vanillin

Downstream raw materials:

2-(4-(benzyloxy)-3-methoxyphenyl)acetonitrile

(3R,4R)-3,4-bis(4-benzyloxy-3-methoxybenzyl)dihydrofuran-2(3H)-one

(3S,4S)-3,4-bis(4-benzyloxy-3-methoxybenzyl)dihydrofuran-2(3H)-one

4-Benzyloxy-3-methoxyphenyl<1-¹⁴C>acetonitril

Refernces

• 1、 -. "Application of gastrodia elata bl derived derivatives to preparation of medicine for treating Inflammatory Bowel disease (IBD)". Paragraph 0052; 0054. . Retrieved 2021/01/20.
• 2、 Hattori, Hiroyuki,Mitsunaga,Clive, Derrick L.J.. "Synthesis of phenolic components of Grains of Paradise". supporting information. p. 1989 - 1991. Retrieved 2019/07/03.