Methyl 3,4-diaminobenzoate

Base Information

• Chemical Name: Methyl 3,4-diaminobenzoate
• CAS No.: 36692-49-6
• Molecular Formula: C8H10N2O2
• Molecular Weight: 166.18
• Hs Code.: 29224999
• Mol file: 36692-49-6.mol

Synonyms:3,4-DIAMINOBENZOIC ACID METHYL ESTER;BUTTPARK 96\50-24;METHYL 3,4-DIAMINOBENZENECARBOXYLATE;METHYL 3,4-DIAMINOBENZOATE;Methyldibromobenzoate;3,4-DIAMINOBENZOIC ACID METHYL ESTER 97%;3 5-DIAMINO-2-METHYL BENZOIC ACID 97%;BENZOICACID,3,4-DIAMINO-,METHYLESTER

Chemical Property of Methyl 3,4-diaminobenzoate

Chemical Property:

• Vapor Pressure: 0.00197mmHg at 25°C
• Melting Point: 108-109 ºC
• Refractive Index: 1.583
• Boiling Point: 376.9 °C at 760 mmHg
• PKA: 3.02±0.10(Predicted)
• Flash Point: 224.6 °C
• PSA: 78.34000
• Density: 1.26 g/cm³
• LogP: 1.80000
• Storage Temp.: Keep in dark place,Sealed in dry,Room Temperature
• Solubility.: soluble in Methanol

Purity/Quality:

98%,99%, ^*data from raw suppliers

Methyl 3,4-diaminobenzoate ^*data from reagent suppliers

Safty Information:

• Hazard Codes: Xi,Xn
• Statements: 36/37/38-20/21/22-22
• Safety Statements: 26-36/37/39-36/37

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

Technology Process of Methyl 3,4-diaminobenzoate

There total 12 articles about Methyl 3,4-diaminobenzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.1%

methanol (67-56-1) + 3,4-diaminobenzoic acid (619-05-6) → Methyl 3,4-diaminobenzoate (36692-49-6)

Guidance literature:

With sulfuric acid; at 90 ℃; for 12h; Temperature;

Reference yield: 96.7%

3-amino-4-nitrobenzoic acid methyl ester (99512-09-1) → Methyl 3,4-diaminobenzoate (36692-49-6)

Guidance literature:

With palladium 10% on activated carbon; hydrogen; In methanol; at 20 ℃; for 4h; Inert atmosphere;

Reference yield: 93.0%

3,4-diaminobenzoic acid (619-05-6) → Methyl 3,4-diaminobenzoate (36692-49-6)

Guidance literature:

With sodium hydroxide; thionyl chloride; sodium chloride; In methanol; dichloromethane;

upstream raw materials:

methyl 4-amino-3-nitrobenzoate

methanol

3,4-diaminobenzoic acid

3,4-dinitrobenzoic acid methyl ester

Downstream raw materials:

2-(4-methoxycarbonyl-phenyl)-1⁽³⁾H-benzimidazole-5-carboxylic acid methyl ester

methyl 2-methylbenzimidazole-5-carboxylate hydrochloride

1,3-Dihydro-2-phenyl-2H-1,3,2-<4-carbomethoxy-benzo-1,2>-diazaphosphol-2-oxid

3-benzylidene-1,2-epoxy-1,3a-diphenyl-2,3,3a,4-tetrahydro-1H-cyclopenta[b]quinoxaline-2,6-dicarboxylic acid dimethyl ester

Refernces

• 1、 Metzler-Nolte, Nils,Miller, Reece G.,Obitz, Daniel. "Synthesis and DNA interaction studies of Ru(ii) cell penetrating peptide (CPP) bioconjugates". . p. 13768 - 13777. Retrieved 2021/10/19.
• 2、 -. "Methyl 1,2,3,4-tetrahydroquinoxaline-6-carboxylate and preparation method thereof". Paragraph 0015; 0025; 0028; 0031; 0034; 0037. . Retrieved 2019/01/08.